HPV16:VE6

Species (Taxon ID)	Human papillomavirus type 16. (333760)
Gene Name(s)	E6
Protein Name(s)	Protein E6
External Links
UniProt	P03126
EMBL	K02718 AF536179 D00735
PIR	A03682
RefSeq	NP_041325.1
PDB	1VZN 2FK4 2KPL 2LJX 2LJY 2LJZ 4GIZ 4JOP
PDBsum	1VZN 2FK4 2KPL 2LJX 2LJY 2LJZ 4GIZ 4JOP
ProteinModelPortal	P03126
SMR	P03126
DIP	DIP-44706N
IntAct	P03126
MINT	MINT-96563
BindingDB	P03126
ChEMBL	CHEMBL2010633
GeneID	1489078
EvolutionaryTrace	P03126
Proteomes	UP000009251
GO	GO:0044204 GO:0003677 GO:0046872 GO:0030165 GO:0032864 GO:0039649 GO:0045944 GO:0039548 GO:0039580 GO:0039502 GO:0006351
InterPro	IPR001334
Pfam	PF00518

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030165	PDZ domain binding	PMID:21139582	ECO:0000021		UniProtKB:O14907 UniProtKB:P03126	F		Binding of HPV E6 and Tip-I’s PDZ domain is shown in: Figure 1 (A) Yeast mating assay confirming that HPV16 E6 binds to short carboxyl terminal of Tip-I’ PDZ domain. The abstract and introduction explain in more detail and make reference to the original paper for these findings (Hampson et al, 2004)	complete
	GO:0043088	regulation of Cdc42 GTPase activity	PMID:21139582	ECO:0000314			P		Fluorescent kinetic analysis of Cdc42 activation by GEF16 in the presence of high-risk HPV16 E6 and Tip-1. Different combinations of 2 mM concentrations of the recombinant proteins GEF16, Tip-1 and HPV16 E6 were added after 4 min of initial readings being taken with Cdc42 and assay buffers alone. Each combination was carried out in triplicate. It can be seen that Cdc42 activation by GEF16 is enhanced in the presence of Tip-1 and E6. HPV16 E6, Tip-1, ARHGEF16 and Cdc42 activation	complete
	GO:0035023	regulation of Rho protein signal transduction	PMID:21139582	ECO:0000314			P		Figure 3 Expression of HPV16 E6 is associated with the upregulation of GEF16 and higher levels of activated Cdc42 in non-transformed cells.Fig3(C) Western immunoblot analysis of GTP-activated Cdc42 in HPV16 E6- and HPV6 E6-transfected hTert cells. hTertT16 E6 cells showed increased levels of activated Cdc42. The addition of GTP to the PAK1 Cdc42 assay shows constitutive GTP activation of the available Cdc42.	complete
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:10400710	ECO:0000315			P		Figure 7. HPV-16 E6 represses the ability of CBP to activate p53-dependent transcription.	complete CACAO 8543
	GO:0039653	suppression by virus of host transcription	PMID:10400710	ECO:0000315			P		Figure 7	complete CACAO 8571
	GO:0039653	suppression by virus of host transcription	1040071:1040071	ECO:0000314			P		Figure 6. 16E6 protein can disrupt an in vitro p53-CBP interaction in in a dose-dependent manner	complete CACAO 8574
involved_in	GO:0039653	suppression by virus of host transcription	PMID:10400710	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21139582	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090630	activation of GTPase activity	PMID:21139582	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:21139582	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14907	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22483108	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03126	F		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001334	C		Seeded From UniProt	complete
involved_in	GO:0039502	suppression by virus of host type I interferon-mediated signaling pathway	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496164	P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496164	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496164	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496164	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496164	P		Seeded From UniProt	complete
involved_in	GO:0039649	modulation by virus of host ubiquitin-protein ligase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496164	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496164	F		Seeded From UniProt	complete
involved_in	GO:0039548	suppression by virus of host IRF3 activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496164	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1035 UniProtKB-SubCell:SL-0381	C		Seeded From UniProt	complete
involved_in	GO:0039548	suppression by virus of host IRF3 activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1092	P		Seeded From UniProt	complete
involved_in	GO:0039526	modulation by virus of host apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1119	P		Seeded From UniProt	complete
involved_in	GO:0039503	suppression by virus of host innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1090	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0030683	evasion or tolerance by virus of host immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0899	P		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1048 UniProtKB-SubCell:SL-0414	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
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References

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