HPV11:VE1

Species (Taxon ID)	Human papillomavirus type 11. (10580)
Gene Name(s)	E1
Protein Name(s)	Replication protein E1 ATP-dependent helicase E1
External Links
UniProt	P04014
EMBL	M14119
PIR	A03659
ProteinModelPortal	P04014
SMR	P04014
IntAct	P04014
MINT	MINT-95113
BindingDB	P04014
ChEMBL	CHEMBL4953
Proteomes	UP000008222
GO	GO:0042025 GO:0005524 GO:0004003 GO:0003677 GO:0030911 GO:0006260
Gene3D	3.40.50.300
InterPro	IPR001177 IPR014000 IPR014015 IPR027417 IPR016393
Pfam	PF00519 PF00524
PIRSF	PIRSF003383
SUPFAM	SSF52540
PROSITE	PS51206

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030911	TPR domain binding	PMID:19008854	ECO:0000021		UniProtKB:P09914	F		Figure S1 and S2. Co-immunoprecipitation assays confirm the binding of ATPase HPV11 E1 to the TPR2 domain of P56 (IFIT1) protein.	complete
	GO:0042025	host cell nucleus	PMID:19008854	ECO:0000314			C		Figure 1E, panel 1 (middle). Immunofluorescence confirms the location of HPV11 E1 in host cell nucleus.	complete
	GO:0019079	viral genome replication	PMID:19008854	ECO:0000314			P		Figure 6A. In vitro DNA replication assay confirms that HPV11 E1 is needed for de novo viral DNA synthesis.	complete
	GO:0004003	ATP-dependent DNA helicase activity	PMID:19008854	ECO:0000314			F		Figure 7A. The release of 32P-labelled oligonucleotide annealed to M13mp18 single-stranded DNA comfirms the ATP-dependent DNA helicase activity of E1.	complete
	GO:0016887	ATPase activity	PMID:19008854	ECO:0000314			F		Figure 7C shows ATPase activity of E1.	complete
enables	GO:0003677	DNA binding	PMID:9804845	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	PMID:12192057	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0039686	bidirectional double-stranded viral DNA replication	PMID:12192057	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003678	DNA helicase activity	PMID:12192057	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034214	protein hexamerization	PMID:12192057	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0039693	viral DNA genome replication		ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030911	TPR domain binding	PMID:19008854	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09914	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001177	F		Seeded From UniProt	complete
enables	GO:0004003	ATP-dependent DNA helicase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001177	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001177	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001177	P		Seeded From UniProt	complete
enables	GO:0016817	hydrolase activity, acting on acid anhydrides	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014000 InterPro:IPR016393	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242300	F		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242300	C		Seeded From UniProt	complete
enables	GO:0004003	ATP-dependent DNA helicase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242300	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242300	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242300	P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1048 UniProtKB-SubCell:SL-0414	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
edit table

References

See Help:References for how to manage references in GONUTS.