HORSE:SCN4A

Species (Taxon ID)	Equus caballus (Horse). (9796)
Gene Name(s)	SCN4A
Protein Name(s)	Sodium channel protein type 4 subunit alpha Sodium channel protein skeletal muscle subunit alpha Sodium channel protein type IV subunit alpha Voltage-gated sodium channel subunit alpha Nav1.4
External Links
UniProt	Q28371
EMBL	U25990
RefSeq	NP_001075230.1
UniGene	Eca.13094
ProteinModelPortal	Q28371
STRING	9796.ENSECAP00000005581
PRIDE	Q28371
GeneID	100049793
KEGG	ecb:100049793
CTD	6329
eggNOG	COG1226
InParanoid	Q28371
KO	K04837
Proteomes	UP000002281
GO	GO:0001518 GO:0005248
Gene3D	1.20.120.350
InterPro	IPR027359 IPR005821 IPR000048 IPR028826 IPR008052 IPR001696 IPR010526
PANTHER	PTHR10037:SF193
Pfam	PF00520 PF06512
PRINTS	PR00170 PR01665
SMART	SM00015
PROSITE	PS50096

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35499	C	Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35499	C	Seeded From UniProt	complete
enables	GO:0005248	voltage-gated sodium channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35499	F	Seeded From UniProt	complete
involved_in	GO:0100001	regulation of skeletal muscle contraction by action potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35499	P	Seeded From UniProt	complete
involved_in	GO:0035725	sodium ion transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35499	P	Seeded From UniProt	complete
involved_in	GO:0086010	membrane depolarization during action potential	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000004140 UniProtKB:Q14524	P	Seeded From UniProt	complete
involved_in	GO:0035725	sodium ion transmembrane transport	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0264255 PANTHER:PTN000798901 RGD:3632 RGD:3637 UniProtKB:Q14524 UniProtKB:Q15858 UniProtKB:Q9Y5Y9	P	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108029 MGI:MGI:1345149 MGI:MGI:98246 MGI:MGI:98248 PANTHER:PTN000798922 RGD:3635	C	Seeded From UniProt	complete
involved_in	GO:0019228	neuronal action potential	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98246 PANTHER:PTN000798901 RGD:3632 RGD:3635 RGD:3638 RGD:69364 RGD:69368	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102965 MGI:MGI:108029 MGI:MGI:1201678 MGI:MGI:1345149 MGI:MGI:98251 PANTHER:PTN000004140 RGD:3638 RGD:68942 RGD:69364 UniProtKB:O43497 UniProtKB:P35498 UniProtKB:Q14524	C	Seeded From UniProt	complete
enables	GO:0005248	voltage-gated sodium channel activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0264255 MGI:MGI:108029 MGI:MGI:1345149 MGI:MGI:98246 MGI:MGI:98248 MGI:MGI:98250 MGI:MGI:98251 PANTHER:PTN000004137 RGD:3629 RGD:3632 RGD:3635 RGD:3638 RGD:69364 RGD:69368 UniProtKB:Q14524 UniProtKB:Q15858 UniProtKB:Q99250 UniProtKB:Q9UQD0 UniProtKB:Q9Y5Y9	F	Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000004137 RGD:3632 RGD:3635 RGD:3638 RGD:69364 RGD:69368 UniProtKB:Q14524 UniProtKB:Q9Y5Y9	C	Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001696 InterPro:IPR008052 InterPro:IPR010526	C	Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F	Seeded From UniProt	complete
enables	GO:0005248	voltage-gated sodium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001696 InterPro:IPR008052 InterPro:IPR010526	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P	Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001696 InterPro:IPR008052 InterPro:IPR010526	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	C	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P	Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
enables	GO:0005272	sodium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0894	F	Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0739	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HORSE:SCN4A

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