GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HHV11:MCP
Contents
| Species (Taxon ID) | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1). (10299) | |
| Gene Name(s) | UL19 | |
| Protein Name(s) | Major capsid protein
MCP Capsid protein VP5 | |
| External Links | ||
| UniProt | P06491 | |
| EMBL | X14112 X04467 | |
| PIR | A27239 | |
| RefSeq | NP_044620.1 | |
| PDB | 1NO7 | |
| PDBsum | 1NO7 | |
| ProteinModelPortal | P06491 | |
| SMR | P06491 | |
| IntAct | P06491 | |
| MINT | MINT-6732551 | |
| GeneID | 2703368 | |
| EvolutionaryTrace | P06491 | |
| Proteomes | UP000009294 | |
| GO | GO:0042025 GO:0039622 GO:0005198 | |
| InterPro | IPR000912 IPR023233 | |
| Pfam | PF03122 | |
| PRINTS | PR00235 | |
| SUPFAM | SSF103417 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0039622 |
T=16 icosahedral viral capsid |
ECO:0000314 |
C |
The authors isolate a 65kda fragment of VP5 by "limited trypsin digestion." They then identifiy this fragment as the upper domain of VP5 by x-ray crystallography. Fig 1. shows this crystalized structure of the upper domain. It identifies areas important for both interactions between VP5 proteins and interactions with other capsid proteins like VP26. The authors also identify a novel fold that is unique to the herpesvirus. |
complete | |||||
| GO:0039622 |
T=16 icosahedral viral capsid |
ECO:0000255 |
|
C |
Fig. 2 identifies VP5 as the major capsid protein through cryoelectron microscopy. The authors fit the crystalized structure of VP5ud (upper domain) on to a cryoelectron microscopy map of the HSV-1 capsid obtained from a publication by Zhou et al (PMID:10797014[3]). They utilize Foldhunter (PMID:11352589[2]) and the Molecular Modeling Toolkit (MMTK) to fit the x-ray structure on to the cryoelectron microscopy map of the capsid. |
complete | ||||
|
enables |
GO:0005198 |
structural molecule activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019028 |
viral capsid |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000304550 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0039622 |
T=16 icosahedral viral capsid |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000304550 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005198 |
structural molecule activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000304550 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0019012 |
virion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019028 |
viral capsid |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0039622 |
T=16 icosahedral viral capsid |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Bowman, BR et al. (2003) Structure of the herpesvirus major capsid protein. EMBO J. 22 757-65 PubMed GONUTS page
- ↑ 2.0 2.1 Jiang, W et al. (2001) Bridging the information gap: computational tools for intermediate resolution structure interpretation. J. Mol. Biol. 308 1033-44 PubMed GONUTS page
- ↑ Zhou, ZH et al. (2000) Seeing the herpesvirus capsid at 8.5 A. Science 288 877-80 PubMed GONUTS page
