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HELPY:HCPB

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Species (Taxon ID) Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori). (85962)
Gene Name(s) hcpB
Protein Name(s) Beta-lactamase HcpB

Cysteine-rich protein B

External Links
UniProt O25103
EMBL AE000511
PIR H64561
PDB 1KLX
PDBsum 1KLX
ProteinModelPortal O25103
SMR O25103
DIP DIP-3342N
IntAct O25103
MINT MINT-160080
STRING 85962.HP0336
PRIDE O25103
EnsemblBacteria AAD07408
PATRIC 20591907
eggNOG COG0790
OMA SIACEAN
OrthoDB EOG6TJ7WZ
BioCyc HPY:HP0336-MONOMER
EvolutionaryTrace O25103
Proteomes UP000000429
GO GO:0008800
GO:0008152
GO:0046677
Gene3D 1.25.40.10
InterPro IPR006597
IPR011990
Pfam PF08238
SMART SM00671

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008800

beta-lactamase activity

PMID:11777911[1]

ECO:0000314

F

Table 1: Purified HcpB hydrolyzes several antibiotics by opening of the beta-lactam ring, which was monitored by absorption variation.

complete
CACAO 6179

enables

GO:0008800

beta-lactamase activity

PMID:11777911[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008800

beta-lactamase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.2.6

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0046677

response to antibiotic

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0046

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Luthy, L et al. (2002) The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein. J. Biol. Chem. 277 10187-93 PubMed GONUTS page