HELPX:Q93UM8

Species (Taxon ID)	Helicobacter pylori (Campylobacter pylori). (210)
Gene Name(s)	vacA (ECO:0000313 with EMBL:AAK56858.1)
Protein Name(s)	VacA (ECO:0000313 with EMBL:AAK56858.1)
External Links
UniProt	Q93UM8
EMBL	AF191643
ProteinModelPortal	Q93UM8
SMR	Q93UM8
GO	GO:0005576 GO:0019867 GO:0009405
Gene3D	2.40.128.130
InterPro	IPR005546 IPR006315 IPR003842
Pfam	PF02691
PRINTS	PR01656
SMART	SM00869
SUPFAM	SSF103515
TIGRFAMs	TIGR01414
PROSITE	PS51208

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0012501	programmed cell death	PMID:21482684	ECO:0000315			P		Figure 1 shows that VacA increases the death of gastric epithelial cells compared to the nonfunctional mutant both when the cells are incubated with supernatant from both H.pylori strains or when incubated with the purified VacA or mutant VacA proteins. Figure 2 shows that VacA causes the cells to swell, implying necrosis and not apoptosis. Figure 8 shows that the pathway in which VacA causes cell death is caspase-independent.	complete CACAO 10435
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003842	C		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003842	P		Seeded From UniProt	complete
part_of	GO:0019867	outer membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006315	C		Seeded From UniProt	complete
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References

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