HELPX:C7F7V2

Species (Taxon ID)	Helicobacter pylori (Campylobacter pylori). (210)
Gene Name(s)	vacA (ECO:0000313 with EMBL:ACT79001.1)
Protein Name(s)	VacA (ECO:0000313 with EMBL:ADK63226.1) Vacuolating cytotoxin (ECO:0000313 with EMBL:ACT79001.1)
External Links
UniProt	C7F7V2
EMBL	GQ338187 GQ338193 GQ338198 GQ338216 GQ338222 HM047572 HM047574 HM047577 HM047597 HM047604 HM047664 HM047713 HM047721 HM047723 HM047728 HM047730 HM047732
GO	GO:0005576 GO:0009405
InterPro	IPR003842
Pfam	PF02691
PRINTS	PR01656

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005773	vacuole	PMID:16436379	ECO:0000314			C		Using immunocytochemistry and confocal analysis, figure 2 shows that VacA is localized to vacuoles, but not to mitochondria.	complete CACAO 3791
	GO:0009405	pathogenesis	PMID:16436379	ECO:0000314			P		Figure 4 (A-F) shows flow cytometric analysis using antibodies specific for active Bax to compare cells that were treated with VacA to cells that were not. Bax was activated when exposed to VacA.	complete CACAO 3793
	GO:0009405	pathogenesis	PMID:16436379	ECO:0000314			P		toxin molecule that attaches to the surface and gets inserted into the cell where it accumulates and effects the normal trafficking of the cells resulting in the death of that cell	complete CACAO 9665
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003842	C		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003842	P		Seeded From UniProt	complete
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References

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