HAEIN:PYRH

Species (Taxon ID)	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd). (71421)
Gene Name(s)	pyrH (synonyms: smbA)
Protein Name(s)	Uridylate kinase UK Uridine monophosphate kinase UMP kinase UMPK
External Links
UniProt	P43890
EMBL	L42023
PIR	H64180
RefSeq	NP_439223.1 WP_005693391.1
PDB	2A1F
PDBsum	2A1F
ProteinModelPortal	P43890
SMR	P43890
STRING	71421.HI1065
DNASU	950042
EnsemblBacteria	AAC22719
GeneID	950042
KEGG	hin:HI1065
PATRIC	20190793
eggNOG	COG0528
KO	K09903
OMA	PIIVFDM
OrthoDB	EOG6M0T8S
PhylomeDB	P43890
SABIO-RK	P43890
UniPathway	UPA00159
EvolutionaryTrace	P43890
Proteomes	UP000000579
GO	GO:0005737 GO:0005524 GO:0033862 GO:0044210
Gene3D	3.40.1160.10
HAMAP	MF_01220_B
InterPro	IPR001048 IPR011817 IPR015963
Pfam	PF00696
PIRSF	PIRSF005650
SUPFAM	SSF53633
TIGRFAMs	TIGR02075

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0033862	UMP kinase activity	PMID:22428584	ECO:0000314			F		Figure 2: UMP kinase activity assays was used to evaluate PyrH kinase activity of S. pneumoniae and H. influenzae verse a sterilized water control. The amount of residual substrate left over, either ATP (labeled RLU) or UMP, was scaled in relative luminescence units versus time. The luminescence units left over were correlated to the amount of PyrH added.	complete
enables	GO:0033862	UMP kinase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11539 PANTHER:PTN000719921 UniProtKB:P9WHK5	F		Seeded From UniProt	complete
involved_in	GO:0006225	UDP biosynthetic process		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000719921 UniProtKB:P9WHK5	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11539 PANTHER:PTN000719927	C		Seeded From UniProt	complete
involved_in	GO:0046940	nucleoside monophosphate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0009041	P		Seeded From UniProt	complete
involved_in	GO:0046940	nucleoside monophosphate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0033862	P		Seeded From UniProt	complete
involved_in	GO:0046940	nucleoside monophosphate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0009041	P		Seeded From UniProt	complete
involved_in	GO:0046940	nucleoside monophosphate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0033862	P		Seeded From UniProt	complete
involved_in	GO:0046940	nucleoside monophosphate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0033862	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015963	C		Seeded From UniProt	complete
involved_in	GO:0006221	pyrimidine nucleotide biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011817 InterPro:IPR015963	P		Seeded From UniProt	complete
enables	GO:0009041	uridylate kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011817	F		Seeded From UniProt	complete
enables	GO:0033862	UMP kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015963	F		Seeded From UniProt	complete
enables	GO:0033862	UMP kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.4.22	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000337822	C		Seeded From UniProt	complete
enables	GO:0009041	uridylate kinase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000337822	F		Seeded From UniProt	complete
involved_in	GO:0006221	pyrimidine nucleotide biosynthetic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000337822	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006221	pyrimidine nucleotide biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0665	P		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0044210	'de novo' CTP biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00159	P		Seeded From UniProt	complete
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