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HAEI8:Q4QL73

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Species (Taxon ID) Haemophilus influenzae (strain 86-028NP). (281310)
Gene Name(s) sapA (ECO:0000313 with EMBL:AAX88224.1)
Protein Name(s) ABC-type transport system, periplasmic component, involved in antimicrobial peptide resistance (ECO:0000313 with EMBL:AAX88224.1)
External Links
UniProt Q4QL73
EMBL CP000057
RefSeq YP_248884.1
ProteinModelPortal Q4QL73
STRING 281310.NTHI1401
EnsemblBacteria AAX88224
GeneID 3430653
KEGG hit:NTHI1401
PATRIC 20182903
eggNOG COG4166
HOGENOM HOG000164955
KO K12368
OMA PILSCGT
OrthoDB EOG63C0PB
BioCyc HINF281310:GJ89-1305-MONOMER
Proteomes UP000002525
GO GO:0005215
InterPro IPR000914
IPR023765
Pfam PF00496
PROSITE PS01040

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0015886

heme transport

PMID:21441512[1]

ECO:0000315

P

Figure 3A&B. The iron-starved parent strain was unable to grow when subcultured in heme-depleted medium, which indicated that the microorganism was sufficiently starved of all internal iron stores. Parent strain growth was restored, however, when the strain was subcultured in the presence of heme. Although the SapA-deficient strain demonstrated growth comparable to that of the parent in a heme-replete environment, following iron starvation, the cells were unable to utilize heme for growth.

complete
CACAO 5998

part_of

GO:0043190

ATP-binding cassette (ABC) transporter complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030678

C

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030678

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Mason, KM et al. (2011) Heme utilization by nontypeable Haemophilus influenzae is essential and dependent on Sap transporter function. J. Bacteriol. 193 2527-35 PubMed GONUTS page