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HAEI8:MURA

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Species (Taxon ID) Haemophilus influenzae (strain 86-028NP). (281310)
Gene Name(s) murA (ECO:0000255 with HAMAP-Rule:MF_00111)
Protein Name(s) UDP-N-acetylglucosamine 1-carboxyvinyltransferase (ECO:0000255 with HAMAP-Rule:MF_00111)

Enoylpyruvate transferase (ECO:0000255 with HAMAP-Rule:MF_00111) UDP-N-acetylglucosamine enolpyruvyl transferase (ECO:0000255 with HAMAP-Rule:MF_00111) EPT (ECO:0000255 with HAMAP-Rule:MF_00111)

External Links
UniProt Q4QLK7
EMBL CP000057
RefSeq YP_248750.1
ProteinModelPortal Q4QLK7
SMR Q4QLK7
STRING 281310.NTHI1244
BindingDB Q4QLK7
EnsemblBacteria AAX88090
GeneID 3430516
KEGG hit:NTHI1244
PATRIC 20182611
eggNOG COG0766
HOGENOM HOG000075602
KO K00790
OMA IRTAPHP
OrthoDB EOG68M4GK
BioCyc HINF281310:GJ89-1168-MONOMER
UniPathway UPA00219
Proteomes UP000002525
GO GO:0005737
GO:0008760
GO:0007049
GO:0051301
GO:0071555
GO:0009252
GO:0008360
GO:0019277
Gene3D 3.65.10.10
HAMAP MF_00111
InterPro IPR001986
IPR013792
IPR005750
PANTHER PTHR21090:SF4
Pfam PF00275
SUPFAM SSF55205
TIGRFAMs TIGR01072

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008760

UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity

PMID:23462005[1]

ECO:0000315

F

Figure 3 demonstrates the inhibitory activities on MurA and then determines the residual activity. Figure 5 demonstrates the inhibitory actions of sulfhydryl group dependent activity on the mutant phenotype.

complete
CACAO 7011

enables

GO:0008760

UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity

PMID:23462005[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013792

F

Seeded From UniProt

complete

enables

GO:0008760

UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005750

F

Seeded From UniProt

complete

enables

GO:0016765

transferase activity, transferring alkyl or aryl (other than methyl) groups

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001986
InterPro:IPR036968

F

Seeded From UniProt

complete

involved_in

GO:0019277

UDP-N-acetylgalactosamine biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005750

P

Seeded From UniProt

complete

enables

GO:0008760

UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.5.1.7

F

Seeded From UniProt

complete

enables

GO:0008760

UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000001460

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000001460

C

Seeded From UniProt

complete

involved_in

GO:0009252

peptidoglycan biosynthetic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000001460

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0071555

cell wall organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0961

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0008360

regulation of cell shape

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0133

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

involved_in

GO:0009252

peptidoglycan biosynthetic process

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0573
UniPathway:UPA00219

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Han, SG et al. (2013) Identification of novel irreversible inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Haemophilus influenzae. J. Microbiol. Biotechnol. 23 329-34 PubMed GONUTS page