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HAEDU:Q7VM01
Contents
| Species (Taxon ID) | Haemophilus ducreyi (strain 35000HP / ATCC 700724). (233412) | |
| Gene Name(s) | sapA (ECO:0000313 with EMBL:AAP96068.1) | |
| Protein Name(s) | Peptide transport periplasmic protein SapA (ECO:0000313 with EMBL:AAP96068.1) | |
| External Links | ||
| UniProt | Q7VM01 | |
| EMBL | AE017143 | |
| RefSeq | NP_873679.1 | |
| ProteinModelPortal | Q7VM01 | |
| STRING | 233412.HD1230 | |
| EnsemblBacteria | AAP96068 | |
| GeneID | 1491141 | |
| KEGG | hdu:HD1230 | |
| PATRIC | 20178781 | |
| KO | K12368 | |
| OMA | PILSCGT | |
| OrthoDB | EOG63C0PB | |
| BioCyc | HDUC233412:GH5F-1119-MONOMER | |
| Proteomes | UP000001022 | |
| GO | GO:0005215 GO:0030682 | |
| InterPro | IPR000914 | |
| Pfam | PF00496 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0009405 |
pathogenesis |
ECO:0000315 |
P |
Table 3. Papule formation not affected, though sapA expression had a significant effect on the ability to progress to pustule formation in humans. Although precluded by biosafety regulations from testing complemented mutants in humans, the data suggest that SapA contributes significantly to the virulence in humans. No suggestions of cross-contamination. |
complete | |||||
| GO:0030682 |
evasion or tolerance of host defense response |
ECO:0000315 |
P |
Figure 3 shows the effect of sapA mutation on resistance to the mammalian defense LL-37. The plasmid-complemented mutant was not significantly different from the parent. No resistance was seen for alpha- and beta- defensins. |
complete | |||||
|
involved_in |
GO:0030682 |
evasion or tolerance of host defense response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043190 |
ATP-binding cassette (ABC) transporter complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055085 |
transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Mount, KL et al. (2010) Haemophilus ducreyi SapA contributes to cathelicidin resistance and virulence in humans. Infect. Immun. 78 1176-84 PubMed GONUTS page
b
