HAEDU:CDTA

Species (Taxon ID)	Haemophilus ducreyi (strain 35000HP / ATCC 700724). (233412)
Gene Name(s)	cdtA
Protein Name(s)	Cytolethal distending toxin subunit A CDT A
External Links
UniProt	O06522
EMBL	U53215 AE017143
RefSeq	NP_873397.1 WP_010944836.1
PDB	1SR4
PDBsum	1SR4
ProteinModelPortal	O06522
SMR	O06522
STRING	233412.HD0902
EnsemblBacteria	AAP95786
GeneID	1490844
KEGG	hdu:HD0902
PATRIC	20178201
eggNOG	NOG46381
KO	K11013
OMA	HREYFRF
OrthoDB	EOG6J1DC9
BioCyc	HDUC233412:GH5F-822-MONOMER
EvolutionaryTrace	O06522
Proteomes	UP000001022
GO	GO:0009279 GO:0030246 GO:0009405
InterPro	IPR015957 IPR003558 IPR000772
Pfam	PF03498
PIRSF	PIRSF036516
PRINTS	PR01387
SUPFAM	SSF50370
PROSITE	PS51257 PS50231

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001907	killing by symbiont of host cells	PMID:11453636	ECO:0000314			P		Figure 2D shows that the eluate of a cdtA mutant strain is not detectably cytotoxic. Cytotoxicity can be restored by mixture of CdtB and CdtC with the sonicated cell lysate of E. coli expressing cdtA. This recovery was not seen upon combination of CdtB and CdtC alone or with the sonicated cell lysate of E.coli carrying a control plasmid (Figure 4, especially 4G vs 4FH).	complete CACAO 5295
involved_in	GO:0009405	pathogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003558	P		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0430	F		Seeded From UniProt	complete
part_of	GO:0009279	cell outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0998 UniProtKB-SubCell:SL-0040	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0090729	toxin activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0800	F		Seeded From UniProt	complete
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References

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