ENTFC:VANX

Species (Taxon ID)	Enterococcus faecium (Streptococcus faecium). (1352)
Gene Name(s)	vanX
Protein Name(s)	D-alanyl-D-alanine dipeptidase (ECO:0000255 with HAMAP-Rule:MF_01924) D-Ala-D-Ala dipeptidase (ECO:0000255 with HAMAP-Rule:MF_01924) Vancomycin B-type resistance protein VanX
External Links
UniProt	Q06241
EMBL	M97297
PIR	S72342
RefSeq	YP_001019034.1 YP_001974795.1 YP_002128400.1 YP_009086374.1 YP_009090105.1 YP_976076.1
PDB	1R44
PDBsum	1R44
ProteinModelPortal	Q06241
SMR	Q06241
BindingDB	Q06241
ChEMBL	CHEMBL1681622
MEROPS	M15.011
GeneID	4670250 4783136 6385878 6779646
BioCyc	MetaCyc:MONOMER-15475
SABIO-RK	Q06241
EvolutionaryTrace	Q06241
GO	GO:0005618 GO:0016805 GO:0046872 GO:0008237 GO:0071555 GO:0046677
Gene3D	3.30.1380.10
HAMAP	MF_01924
InterPro	IPR009045 IPR000755
Pfam	PF01427
PIRSF	PIRSF026671
SUPFAM	SSF55166

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010628	positive regulation of gene expression	PMID:8981985	ECO:0000314			P		Fig. 4 shows production of VanX can be induced by different vancomycin concentrations. Expression of VanX is positively regulated in presence of vancomycin.	complete CACAO 11321
Contributes to	GO:0016805	dipeptidase activity	PMID:9702193	ECO:0000255		UniProtKB:Q06241	F		It is inferred that the protein VanX has dipeptidase properties based on it's similarities in structure to the known murine Sonic Hedgehog (an N-terminal fragment composing the hydrolytic functionality) and the D-ala-D-ala-carboxypeptidase S.Albus(composing the peptidase functionality). Fig 6A shows the alignment comparison of all three; VanX and MSH overlap for 92 alpha carbons, and VanX and S.Albus overlap for 114 alpha carbons. 6B shows at least 7 major homologous overlaps between VanX, MSH and S.Albus. In 6A, the superfamily relationship amongst VanX, MSH and S.Albus is validated by the similarities in active site location;in VanX it is located within residues 83-111, which aligns almost exact with MSH and S.Albus.	complete CACAO 12640
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000755	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000755	F		Seeded From UniProt	complete
enables	GO:0016805	dipeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000755	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000161610	F		Seeded From UniProt	complete
enables	GO:0016805	dipeptidase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000161610	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0046	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0071555	cell wall organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0961	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016805	dipeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0224	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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References

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