ECOLX:E2D2R3

Species (Taxon ID)	Escherichia coli. (562)
Gene Name(s)	dkgA (ECO:0000313 with EMBL:ADK47405.1)
Protein Name(s)	2,5-didehydrogluconate reductase (ECO:0000313 with EMBL:CDP73911.1) 2,5-diketo-D-gluconate reductase [multifunctional] (ECO:0000313 with EMBL:CDY61558.1) 2,5-diketo-D-gluconic acid reductase (ECO:0000313 with EMBL:AHM29898.1) 2,5-diketo-D-gluconic acid reductase A (ECO:0000313 with EMBL:CEE06113.1) DkgA (ECO:0000313 with EMBL:ADK47405.1)
External Links
UniProt	E2D2R3
EMBL	GQ478251 CP007265 CP007390 CP007391 CP007392 CP007393 CP007394 CCCP010000038 HG976963 LM993812 LM995446 CCNI01000039 JFFO01000067 JFFN01000072 JFFJ01000048 JHEW01000032 JHEZ01000023 JNBX01000087 JMIZ01000006 JMJD01000003 JMJE01000013 JEND02000001 JENE03000001 JNNL01000017 JNNJ01000040 JNNK01000008 JNNI01000006 JRBB01000057 JPKJ01000005 JPKH01000003 JPKK01000005 JPKL01000009 JPMZ01000002
SMR	E2D2R3
PRIDE	E2D2R3
EnsemblBacteria	AHM29898
GO	GO:0050580
Gene3D	3.20.20.100
InterPro	IPR001395 IPR018170 IPR020471 IPR023210
PANTHER	PTHR11732
Pfam	PF00248
PIRSF	PIRSF000097
PRINTS	PR00069
SUPFAM	SSF51430
PROSITE	PS00798 PS00062 PS00063

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0050580	2,5-didehydrogluconate reductase activity	PMID:19429550	ECO:0000316		UniProtKB:E2D2R2	F		Figure 5: when expressed from plasmids, dkgA was found to decrease furfural tolerance. Figure 6: Deletions of dkgA caused an increase in furfural tolerance and a decrease in furfural reductase activity in vivo similar to the results shown in the EMFR9 strain of E. coli. Since deletion of dkgA alone did not lower the in vivo reductase activity or increase furfural tolerance, another gene, yqhD, is presumed to be the more important activity for growth inhibition by low concentrations of furfural. The lowest furfural reductase activity, however, was found after deletion of both genes as seen in Figure 3.	complete CACAO 7933
enables	GO:0050580	2,5-didehydrogluconate reductase activity	PMID:19429550	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:E2D2R2	F		Seeded From UniProt	complete
enables	GO:0050580	2,5-didehydrogluconate reductase activity	PMID:19429550	ECO:0000316	genetic interaction evidence used in manual assertion		F		Seeded From UniProt	Missing: with/from
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018170 InterPro:IPR020471	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018170 InterPro:IPR020471	P		Seeded From UniProt	complete
enables	GO:0050580	2,5-didehydrogluconate reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.274	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
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