ECOLI:mntH

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	mntH (ECO:0000255 with HAMAP-Rule:MF_00221) (synonyms: yfeP)
Protein Name(s)	Divalent metal cation transporter MntH (ECO:0000255 with HAMAP-Rule:MF_00221)
External Links
UniProt	P0A769
EMBL	AF161318 U00096 AP009048
PIR	E65013
RefSeq	NP_416893.1 YP_490633.1
ProteinModelPortal	P0A769
DIP	DIP-48004N
IntAct	P0A769
STRING	511145.b2392
TCDB	2.A.55.3.1
EnsemblBacteria	AAC75451 BAA16262
GeneID	12930189 946899
KEGG	ecj:Y75_p2358 eco:b2392
PATRIC	32120161
EchoBASE	EB3909
EcoGene	EG14157
eggNOG	COG1914
HOGENOM	HOG000152205
InParanoid	P0A769
KO	K03322
OMA	AFHFNGH
OrthoDB	EOG654P21
PhylomeDB	P0A769
BioCyc	EcoCyc:YFEP-MONOMER ECOL316407:JW2388-MONOMER MetaCyc:YFEP-MONOMER
PRO	PR:P0A769
Proteomes	UP000000318 UP000000625
Genevestigator	P0A769
GO	GO:0016021 GO:0005886 GO:0015086 GO:0015078 GO:0005384 GO:0046872 GO:0015293 GO:0015292 GO:0070574 GO:0015691 GO:0034599 GO:0006824 GO:0015684 GO:1902600 GO:0006826 GO:0071421 GO:0006828 GO:0030001 GO:0055085
HAMAP	MF_00221
InterPro	IPR001046
PANTHER	PTHR11706
Pfam	PF01566
PRINTS	PR00447
TIGRFAMs	TIGR01197

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0015684	ferrous iron transport	PMID:10712688^[1]	ECO:0000315			P	preference for Mn(II)	complete
	GO:0030001	metal ion transport	PMID:10712688^[1]	ECO:0000315			P	Mn(II) and Fe (II)	complete
	GO:0005886	plasma membrane	PMID:14607838^[2]	ECO:0000314			C	Using Cat (chloramphenicol resistance) and bla (beta-lactamase, ampicillin resistance) fusions.	complete
	GO:0005887	integral to plasma membrane	PMID:14607838^[2]	ECO:0000314			C	Using cat (chloramphenicol resistance) & bla (ampicillin resistance) fusions.	complete
	GO:0030001	metal ion transport	PMID:14607838^[2]	ECO:0000315			P	Cd(II)	complete
involved_in	GO:0071281	cellular response to iron ion	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194568 UniProtKB:Q89K67 UniProtKB:Q8ZCK2	P	Seeded From UniProt	complete
enables	GO:0015086	cadmium ion transmembrane transporter activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG14157 PANTHER:PTN000194431 RGD:3684 TAIR:locus:2025677 TAIR:locus:2200437 UniProtKB:P49281 UniProtKB:P51027	F	Seeded From UniProt	complete
enables	GO:0005384	manganese ion transmembrane transporter activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG14157 FB:FBgn0011672 MGI:MGI:1345275 PANTHER:PTN000194431 RGD:3684 TAIR:locus:2025677 TAIR:locus:2036751 UniProtKB:P49281	F	Seeded From UniProt	complete
involved_in	GO:0030001	metal ion transport	PMID:14607838^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030001	metal ion transport	PMID:10712688^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:14607838^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0015691	cadmium ion transport	PMID:15641799^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0015691	cadmium ion transport	PMID:18227061^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0015293	symporter activity	PMID:18227061^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0015292	uniporter activity	PMID:10712688^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0015086	cadmium ion transmembrane transporter activity	PMID:15641799^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0015078	proton transmembrane transporter activity	PMID:15641799^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006828	manganese ion transport	PMID:15641799^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006826	iron ion transport	PMID:15641799^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006826	iron ion transport	PMID:10712688^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006824	cobalt ion transport	PMID:15641799^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14607838^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005384	manganese ion transmembrane transporter activity	PMID:15641799^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006828	manganese ion transport	PMID:10712688^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15919996^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0015293	P	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015293	P	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015292	P	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0015293	P	Seeded From UniProt	complete
involved_in	GO:0070574	cadmium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015086	P	Seeded From UniProt	complete
involved_in	GO:0070574	cadmium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015086	P	Seeded From UniProt	complete
involved_in	GO:0071421	manganese ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005384	P	Seeded From UniProt	complete
involved_in	GO:0071421	manganese ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005384	P	Seeded From UniProt	complete
involved_in	GO:1902600	proton transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015078	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001046	C	Seeded From UniProt	complete
involved_in	GO:0030001	metal ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001046	P	Seeded From UniProt	complete
enables	GO:0046873	metal ion transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001046	F	Seeded From UniProt	complete
enables	GO:0015293	symporter activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000081080	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000081080	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000081080	C	Seeded From UniProt	complete
involved_in	GO:0030001	metal ion transport	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000081080	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0997 UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0037	C	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0015293	symporter activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0769	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Makui, H et al. (2000) Identification of the Escherichia coli K-12 Nramp orthologue (MntH) as a selective divalent metal ion transporter. Mol. Microbiol. 35 1065-78 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Courville, P et al. (2004) Determination of transmembrane topology of the Escherichia coli natural resistance-associated macrophage protein (Nramp) ortholog. J. Biol. Chem. 279 3318-26 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Chaloupka, R et al. (2005) Identification of functional amino acids in the Nramp family by a combination of evolutionary analysis and biophysical studies of metal and proton cotransport in vivo. Biochemistry 44 726-33 PubMed GONUTS page
↑ ^5.0 ^5.1 Courville, P et al. (2008) Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. J. Biol. Chem. 283 9651-8 PubMed GONUTS page
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page

[PMID:10712688-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Makui, H et al. (2000) Identification of the Escherichia coli K-12 Nramp orthologue (MntH) as a selective divalent metal ion transporter. Mol. Microbiol. 35 1065-78 PubMed GONUTS page

[PMID:14607838-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Courville, P et al. (2004) Determination of transmembrane topology of the Escherichia coli natural resistance-associated macrophage protein (Nramp) ortholog. J. Biol. Chem. 279 3318-26 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15641799-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Chaloupka, R et al. (2005) Identification of functional amino acids in the Nramp family by a combination of evolutionary analysis and biophysical studies of metal and proton cotransport in vivo. Biochemistry 44 726-33 PubMed GONUTS page

[PMID:18227061-5] 5.0 ^5.1 Courville, P et al. (2008) Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. J. Biol. Chem. 283 9651-8 PubMed GONUTS page

[PMID:15919996-6] Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page

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ECOLI:mntH

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