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ECOLI:YOEB
Contents
| Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
| Gene Name(s) | yoeB | |
| Protein Name(s) | Toxin YoeB
Putative endoribonuclease YoeB Putative mRNA interferase Yoeb | |
| External Links | ||
| UniProt | P69348 | |
| EMBL | U00096 AP009048 | |
| RefSeq | YP_490259.1 YP_588458.1 | |
| PDB | 2A6Q 2A6R 2A6S | |
| PDBsum | 2A6Q 2A6R 2A6S | |
| ProteinModelPortal | P69348 | |
| SMR | P69348 | |
| IntAct | P69348 | |
| STRING | 511145.b4539 | |
| EnsemblBacteria | ABD18681 BAE76569 | |
| GeneID | 12931408 1450274 | |
| KEGG | ecj:Y75_p1979 eco:b4539 | |
| PATRIC | 32119369 | |
| EchoBASE | EB4102 | |
| EcoGene | EG14356 | |
| eggNOG | COG4115 | |
| HOGENOM | HOG000216470 | |
| InParanoid | P69348 | |
| KO | K01175 | |
| OMA | GEHRLVY | |
| OrthoDB | EOG6KWZ5K | |
| PhylomeDB | P69348 | |
| BioCyc | EcoCyc:MONOMER0-1041 ECOL316407:JW5331-MONOMER MetaCyc:MONOMER0-1041 | |
| EvolutionaryTrace | P69348 | |
| PRO | PR:P69348 | |
| Proteomes | UP000000318 UP000000625 | |
| Genevestigator | P69348 | |
| GO | GO:0004521 GO:0016892 GO:0043024 GO:0003723 GO:0003714 GO:0006402 GO:0006379 GO:1903507 GO:0045947 GO:0006355 GO:0090502 GO:0044010 GO:0006351 | |
| InterPro | IPR009614 | |
| Pfam | PF06769 | |
| TIGRFAMs | TIGR02116 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008428 |
ribonuclease inhibitor activity |
ECO:0000269 |
F |
Figure 1 shows the down-regulation of RNase III activity by YmdB. |
complete | |||||
|
involved_in |
GO:0098795 |
mRNA cleavage involved in gene silencing |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045947 |
negative regulation of translational initiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG14356 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043024 |
ribosomal small subunit binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG14356 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016892 |
endoribonuclease activity, producing 3'-phosphomonoesters |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG14356 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006401 |
RNA catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002210985 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003714 |
transcription corepressor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG14356 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045947 |
negative regulation of translational initiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044010 |
single-species biofilm formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043024 |
ribosomal small subunit binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016892 |
endoribonuclease activity, producing 3'-phosphomonoesters |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006402 |
mRNA catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004521 |
endoribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090502 |
RNA phosphodiester bond hydrolysis, endonucleolytic |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004521 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090502 |
RNA phosphodiester bond hydrolysis, endonucleolytic |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0016892 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090502 |
RNA phosphodiester bond hydrolysis, endonucleolytic |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0016892 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903507 |
negative regulation of nucleic acid-templated transcription |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0003714 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004519 |
endonuclease activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006401 |
RNA catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004518 |
nuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004519 |
endonuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kim, KS et al. (2008) YmdB: a stress-responsive ribonuclease-binding regulator of E. coli RNase III activity. Genes Dev. 22 3497-508 PubMed GONUTS page
- ↑ Christensen, SK et al. (2004) Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM-yoeB toxin-antitoxin system. Mol. Microbiol. 51 1705-17 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 Zhang, Y & Inouye, M (2009) The inhibitory mechanism of protein synthesis by YoeB, an Escherichia coli toxin. J. Biol. Chem. 284 6627-38 PubMed GONUTS page
- ↑ Kim, Y et al. (2009) Toxin-antitoxin systems in Escherichia coli influence biofilm formation through YjgK (TabA) and fimbriae. J. Bacteriol. 191 1258-67 PubMed GONUTS page
- ↑ Feng, S et al. (2013) YoeB-ribosome structure: a canonical RNase that requires the ribosome for its specific activity. Nucleic Acids Res. 41 9549-56 PubMed GONUTS page
- ↑ Christensen-Dalsgaard, M & Gerdes, K (2008) Translation affects YoeB and MazF messenger RNA interferase activities by different mechanisms. Nucleic Acids Res. 36 6472-81 PubMed GONUTS page
- ↑ Kamada, K & Hanaoka, F (2005) Conformational change in the catalytic site of the ribonuclease YoeB toxin by YefM antitoxin. Mol. Cell 19 497-509 PubMed GONUTS page
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