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ECOLI:TOP1
Contents
| Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
| Gene Name(s) | topA (ECO:0000255 with HAMAP-Rule:MF_00952) (synonyms: supX) | |
| Protein Name(s) | DNA topoisomerase 1 (ECO:0000255 with HAMAP-Rule:MF_00952)
DNA topoisomerase I (ECO:0000255 with HAMAP-Rule:MF_00952) Omega-protein Relaxing enzyme Swivelase Untwisting enzyme | |
| External Links | ||
| UniProt | P06612 | |
| EMBL | X04475 M15041 U00096 AP009048 | |
| PIR | E64875 | |
| RefSeq | NP_415790.1 YP_489542.1 | |
| PDB | 1CY0 1CY1 1CY2 1CY4 1CY6 1CY7 1CY8 1CY9 1CYY 1ECL 1MW8 1MW9 1YUA 3PWT 3PX7 | |
| PDBsum | 1CY0 1CY1 1CY2 1CY4 1CY6 1CY7 1CY8 1CY9 1CYY 1ECL 1MW8 1MW9 1YUA 3PWT 3PX7 | |
| ProteinModelPortal | P06612 | |
| SMR | P06612 | |
| DIP | DIP-11011N | |
| IntAct | P06612 | |
| MINT | MINT-1218330 | |
| STRING | 511145.b1274 | |
| PaxDb | P06612 | |
| PRIDE | P06612 | |
| EnsemblBacteria | AAC74356 BAA14811 | |
| GeneID | 12930585 945862 | |
| KEGG | ecj:Y75_p1248 eco:b1274 | |
| PATRIC | 32117806 | |
| EchoBASE | EB1006 | |
| EcoGene | EG11013 | |
| eggNOG | COG0551 | |
| HOGENOM | HOG000004018 | |
| InParanoid | P06612 | |
| KO | K03168 | |
| OMA | VVECDKC | |
| OrthoDB | EOG6S7XQ9 | |
| PhylomeDB | P06612 | |
| BioCyc | EcoCyc:EG11013-MONOMER ECOL316407:JW1266-MONOMER MetaCyc:EG11013-MONOMER | |
| EvolutionaryTrace | P06612 | |
| PRO | PR:P06612 | |
| Proteomes | UP000000318 UP000000625 | |
| Genevestigator | P06612 | |
| GO | GO:0005694 GO:0003677 GO:0003916 GO:0003917 GO:0003918 GO:0000287 GO:0022616 GO:0006265 | |
| Gene3D | 1.10.460.10 2.70.20.10 3.40.50.140 | |
| HAMAP | MF_00952 | |
| InterPro | IPR000380 IPR003601 IPR023406 IPR013497 IPR013824 IPR013825 IPR023405 IPR003602 IPR013498 IPR005733 IPR013263 IPR028612 IPR006171 | |
| PANTHER | PTHR11390 | |
| Pfam | PF08272 PF01131 PF01751 PF01396 | |
| PRINTS | PR00417 | |
| SMART | SM00437 SM00436 SM00493 | |
| SUPFAM | SSF56712 | |
| TIGRFAMs | TIGR01051 | |
| PROSITE | PS00396 PS50880 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
EcoliWiki:gyrA |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003917 |
DNA topoisomerase type I activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003916 |
DNA topoisomerase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000380 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003916 |
DNA topoisomerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR003601 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003917 |
DNA topoisomerase type I activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000380 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000380 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000106158 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003917 |
DNA topoisomerase type I activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000106158 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016853 |
isomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003916 |
DNA topoisomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Zechiedrich, EL et al. (2000) Roles of topoisomerases in maintaining steady-state DNA supercoiling in Escherichia coli. J. Biol. Chem. 275 8103-13 PubMed GONUTS page
- ↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
- ↑ Massé, E & Drolet, M (1999) Relaxation of transcription-induced negative supercoiling is an essential function of Escherichia coli DNA topoisomerase I. J. Biol. Chem. 274 16654-8 PubMed GONUTS page
- ↑ Pruss, GJ et al. (1982) Escherichia coli DNA topoisomerase I mutants: increased supercoiling is corrected by mutations near gyrase genes. Cell 31 35-42 PubMed GONUTS page
