ECOLI:SULA

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	sulA (synonyms: sfiA)
Protein Name(s)	Cell division inhibitor SulA
External Links
UniProt	P0AFZ5
EMBL	V00307 U00096 AP009048 V00358
PIR	A29016
RefSeq	NP_415478.1 YP_489230.1
ProteinModelPortal	P0AFZ5
SMR	P0AFZ5
DIP	DIP-10945N
IntAct	P0AFZ5
STRING	511145.b0958
ChEMBL	CHEMBL1287594
EnsemblBacteria	AAC74044 BAA35716
GeneID	12930659 947335
KEGG	ecj:Y75_p0930 eco:b0958
PATRIC	32117135
EchoBASE	EB0977
EcoGene	EG10984
HOGENOM	HOG000290470
KO	K13053
OMA	YGFIMRP
OrthoDB	EOG6R5C7P
BioCyc	EcoCyc:EG10984-MONOMER ECOL316407:JW0941-MONOMER
PRO	PR:P0AFZ5
Proteomes	UP000000318 UP000000625
Genevestigator	P0AFZ5
GO	GO:0009276 GO:0000917 GO:0006974 GO:0006281 GO:0051782 GO:0032466 GO:0009432
Gene3D	3.40.50.300
HAMAP	MF_01179
InterPro	IPR004596 IPR027417
Pfam	PF03846
PIRSF	PIRSF003093
SUPFAM	SSF52540
TIGRFAMs	TIGR00623

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0032466	negative regulation of cytokinesis	PMID:9501185^[1]	ECO:0000315			P	Figure 1A indicates with arrows a lack of Z ring formation when MalE-SulA is present within the cell. After mutating the SulA to SulA10 the Z rings are reconstructed and cytokinesis can resume.	complete CACAO 7435
involved_in	GO:0032466	negative regulation of cytokinesis	PMID:9501185^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
	GO:0051782	negative regulation of cell division	PMID:8432706^[2]	ECO:0000315			P	FIG 1A and 1B, expression of sulA inhibits FtsZ localization at division site and induces filamentation	complete CACAO 11016
involved_in	GO:0009432	SOS response	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10984 PANTHER:PTN002176549 UniProtKB:Q9HZJ8 UniProtKB:Q9I5Q0 UniProtKB:Q9I5Q1	P	Seeded From UniProt	complete
involved_in	GO:0051782	negative regulation of cell division	PMID:6998947^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032466	negative regulation of cytokinesis	PMID:6087326^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:11967071^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000245	negative regulation of FtsZ-dependent cytokinesis	PMID:9501185^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034260	negative regulation of GTPase activity	PMID:9501185^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032272	negative regulation of protein polymerization	PMID:9501185^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009432	SOS response	PMID:6361003^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009432	SOS response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004596	P	Seeded From UniProt	complete
involved_in	GO:0051782	negative regulation of cell division	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004596	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000100862	P	Seeded From UniProt	complete
involved_in	GO:0009432	SOS response	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000100862	P	Seeded From UniProt	complete
involved_in	GO:0051782	negative regulation of cell division	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000100862	P	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
involved_in	GO:0009432	SOS response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0742	P	Seeded From UniProt	complete
involved_in	GO:0000917	division septum assembly	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0717	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Mukherjee, A et al. (1998) Inhibition of FtsZ polymerization by SulA, an inhibitor of septation in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 95 2885-90 PubMed GONUTS page
↑ Bi, E & Lutkenhaus, J (1993) Cell division inhibitors SulA and MinCD prevent formation of the FtsZ ring. J. Bacteriol. 175 1118-25 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Huisman, O et al. (1980) Further characterization of sfiA and sfiB mutations in Escherichia coli. J. Bacteriol. 144 185-91 PubMed GONUTS page
↑ Huisman, O et al. (1984) Cell-division control in Escherichia coli: specific induction of the SOS function SfiA protein is sufficient to block septation. Proc. Natl. Acad. Sci. U.S.A. 81 4490-4 PubMed GONUTS page
↑ Khil, PP & Camerini-Otero, RD (2002) Over 1000 genes are involved in the DNA damage response of Escherichia coli. Mol. Microbiol. 44 89-105 PubMed GONUTS page
↑ Quillardet, P & Hofnung, M (1984) Induction by UV light of the SOS function sfiA in Escherichia coli strains deficient or proficient in excision repair. J. Bacteriol. 157 35-8 PubMed GONUTS page

[PMID:9501185-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Mukherjee, A et al. (1998) Inhibition of FtsZ polymerization by SulA, an inhibitor of septation in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 95 2885-90 PubMed GONUTS page

[PMID:8432706-2] Bi, E & Lutkenhaus, J (1993) Cell division inhibitors SulA and MinCD prevent formation of the FtsZ ring. J. Bacteriol. 175 1118-25 PubMed GONUTS page

[PMID:21873635-3] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:6998947-4] Huisman, O et al. (1980) Further characterization of sfiA and sfiB mutations in Escherichia coli. J. Bacteriol. 144 185-91 PubMed GONUTS page

[PMID:6087326-5] Huisman, O et al. (1984) Cell-division control in Escherichia coli: specific induction of the SOS function SfiA protein is sufficient to block septation. Proc. Natl. Acad. Sci. U.S.A. 81 4490-4 PubMed GONUTS page

[PMID:11967071-6] Khil, PP & Camerini-Otero, RD (2002) Over 1000 genes are involved in the DNA damage response of Escherichia coli. Mol. Microbiol. 44 89-105 PubMed GONUTS page

[PMID:6361003-7] Quillardet, P & Hofnung, M (1984) Induction by UV light of the SOS function sfiA in Escherichia coli strains deficient or proficient in excision repair. J. Bacteriol. 157 35-8 PubMed GONUTS page

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ECOLI:SULA

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