ECOLI:SRMB

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	srmB (ECO:0000255 with HAMAP-Rule:MF_00967) (synonyms: rbaB, rhlA)
Protein Name(s)	ATP-dependent RNA helicase SrmB (ECO:0000255 with HAMAP-Rule:MF_00967)
External Links
UniProt	P21507
EMBL	X14152 D13169 D64044 U00096 AP009048
PIR	G65035
RefSeq	NP_417071.1 YP_490804.1
PDB	2YJT
PDBsum	2YJT
ProteinModelPortal	P21507
SMR	P21507
BioGrid	851393
DIP	DIP-10920N
IntAct	P21507
MINT	MINT-1225512
STRING	511145.b2576
PaxDb	P21507
PRIDE	P21507
EnsemblBacteria	AAC75629 BAE76752
GeneID	12934372 947055
KEGG	ecj:Y75_p2529 eco:b2576
PATRIC	32120551
EchoBASE	EB0968
EcoGene	EG10975
eggNOG	COG0513
HOGENOM	HOG000268807
InParanoid	P21507
KO	K05590
OMA	QEKGFTR
OrthoDB	EOG6GBMBM
PhylomeDB	P21507
BioCyc	EcoCyc:EG10975-MONOMER ECOL316407:JW2560-MONOMER
PRO	PR:P21507
Proteomes	UP000000318 UP000000625
Genevestigator	P21507
GO	GO:0005737 GO:0005524 GO:0004004 GO:0008143 GO:0033592 GO:0008186 GO:0006200 GO:0000027
Gene3D	3.40.50.300
HAMAP	MF_00967
InterPro	IPR011545 IPR028621 IPR014001 IPR001650 IPR027417 IPR000629 IPR014014
Pfam	PF00270 PF00271
SMART	SM00487 SM00490
SUPFAM	SSF52540
PROSITE	PS00039 PS51192 PS51194 PS51195

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0008186	RNA-dependent ATPase activity	PMID:2461520^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008143	poly(A) binding	PMID:2461520^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:19393667^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004004	ATP-dependent RNA helicase activity	PMID:19393667^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0033592	RNA strand annealing activity	PMID:21378185^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18304323^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004004	ATP-dependent RNA helicase activity	PMID:15196029^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000027	ribosomal large subunit assembly	PMID:12787353^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000027	ribosomal large subunit assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028621	P	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F	Seeded From UniProt	complete
enables	GO:0004004	ATP-dependent RNA helicase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028621	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112451	F	Seeded From UniProt	complete
involved_in	GO:0000027	ribosomal large subunit assembly	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112451	P	Seeded From UniProt	complete
enables	GO:0004004	ATP-dependent RNA helicase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112451	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112451	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
involved_in	GO:0042254	ribosome biogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0690	P	Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Nishi, K et al. (1988) An eIF-4A-like protein is a suppressor of an Escherichia coli mutant defective in 50S ribosomal subunit assembly. Nature 336 496-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Del Campo, M et al. (2009) Unwinding by local strand separation is critical for the function of DEAD-box proteins as RNA chaperones. J. Mol. Biol. 389 674-93 PubMed GONUTS page
↑ Zhao, X & Jain, C (2011) DEAD-box proteins from Escherichia coli exhibit multiple ATP-independent activities. J. Bacteriol. 193 2236-41 PubMed GONUTS page
↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
↑ Bizebard, T et al. (2004) Studies on three E. coli DEAD-box helicases point to an unwinding mechanism different from that of model DNA helicases. Biochemistry 43 7857-66 PubMed GONUTS page
↑ Charollais, J et al. (2003) The DEAD-box RNA helicase SrmB is involved in the assembly of 50S ribosomal subunits in Escherichia coli. Mol. Microbiol. 48 1253-65 PubMed GONUTS page

[PMID:2461520-1] 1.0 ^1.1 Nishi, K et al. (1988) An eIF-4A-like protein is a suppressor of an Escherichia coli mutant defective in 50S ribosomal subunit assembly. Nature 336 496-8 PubMed GONUTS page

[PMID:19393667-2] 2.0 ^2.1 Del Campo, M et al. (2009) Unwinding by local strand separation is critical for the function of DEAD-box proteins as RNA chaperones. J. Mol. Biol. 389 674-93 PubMed GONUTS page

[PMID:21378185-3] Zhao, X & Jain, C (2011) DEAD-box proteins from Escherichia coli exhibit multiple ATP-independent activities. J. Bacteriol. 193 2236-41 PubMed GONUTS page

[PMID:18304323-4] Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page

[PMID:15196029-5] Bizebard, T et al. (2004) Studies on three E. coli DEAD-box helicases point to an unwinding mechanism different from that of model DNA helicases. Biochemistry 43 7857-66 PubMed GONUTS page

[PMID:12787353-6] Charollais, J et al. (2003) The DEAD-box RNA helicase SrmB is involved in the assembly of 50S ribosomal subunits in Escherichia coli. Mol. Microbiol. 48 1253-65 PubMed GONUTS page

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ECOLI:SRMB

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