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ECOLI:SPOT

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) spoT
Protein Name(s) Bifunctional (p)ppGpp synthase/hydrolase SpoT

GTP pyrophosphokinase (p)ppGpp synthase ATP:GTP 3'-pyrophosphotransferase Stringent response-like protein ppGpp synthase II Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Penta-phosphate guanosine-3'-pyrophosphohydrolase (ppGpp)ase

External Links
UniProt P0AG24
EMBL M24503
L10328
U00096
AP009048
PIR B30374
RefSeq NP_418107.1
YP_491784.1
ProteinModelPortal P0AG24
SMR P0AG24
DIP DIP-29378N
IntAct P0AG24
MINT MINT-1219858
STRING 511145.b3650
PaxDb P0AG24
PRIDE P0AG24
EnsemblBacteria AAC76674
BAE77643
GeneID 12930367
948159
KEGG ecj:Y75_p3524
eco:b3650
PATRIC 32122787
EchoBASE EB0959
EcoGene EG10966
eggNOG COG0317
HOGENOM HOG000018299
InParanoid P0AG24
KO K01139
OMA LDWLNFV
OrthoDB EOG6SV551
PhylomeDB P0AG24
BioCyc EcoCyc:SPOT-MONOMER
ECOL316407:JW3625-MONOMER
MetaCyc:SPOT-MONOMER
UniPathway UPA00908
UPA00908
PRO PR:P0AG24
Proteomes UP000000318
UP000000625
Genevestigator P0AG24
GO GO:0005737
GO:0016597
GO:0008728
GO:0008893
GO:0016301
GO:0015970
GO:0015949
Gene3D 3.10.20.30
InterPro IPR002912
IPR012675
IPR003607
IPR006674
IPR004811
IPR007685
IPR004095
IPR012676
Pfam PF01966
PF04607
PF02824
SMART SM00471
SM00954
SUPFAM SSF81271
TIGRFAMs TIGR00691
PROSITE PS51671

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0042594

response to starvation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10966
PANTHER:PTN001083175

P

Seeded From UniProt

complete

involved_in

GO:0015969

guanosine tetraphosphate metabolic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10835
EcoGene:EG10966
PANTHER:PTN001083175

P

Seeded From UniProt

complete

enables

GO:0008893

guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10966
PANTHER:PTN001083175

F

Seeded From UniProt

complete

enables

GO:0008728

GTP diphosphokinase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10835
PANTHER:PTN001083175

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000479633
UniProtKB:P9WHG9

C

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000479633
UniProtKB:P9WHG9

C

Seeded From UniProt

complete

involved_in

GO:0015949

nucleobase-containing small molecule interconversion

PMID:319345[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008893

guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity

PMID:365225[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0015969

guanosine tetraphosphate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004811
InterPro:IPR007685

P

Seeded From UniProt

complete

enables

GO:0008893

guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.7.2

F

Seeded From UniProt

complete

enables

GO:0008728

GTP diphosphokinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.6.5

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0015970

guanosine tetraphosphate biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00908

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. Fiil, NP et al. (1977) Interaction of alleles of the relA, relC and spoT genes in Escherichia coli: analysis of the interconversion of GTP, ppGpp and pppGpp. Mol. Gen. Genet. 150 87-101 PubMed GONUTS page
  3. Heinemeyer, EA & Richter, D (1978) Characterization of the guanosine 5'-triphosphate 3'-diphosphate and guanosine 5'-diphosphate 3'-diphosphate degradation reaction catalyzed by a specific pyrophosphorylase from Escherichia coli. Biochemistry 17 5368-72 PubMed GONUTS page
  4. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page