ECOLI:SLYA

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	slyA (ECO:0000255 with HAMAP-Rule:MF_01819)
Protein Name(s)	Transcriptional regulator SlyA (ECO:0000255 with HAMAP-Rule:MF_01819)
External Links
UniProt	P0A8W2
EMBL	AJ010965 Y11194 U00096 AP009048
PIR	S70929
RefSeq	NP_416159.2 WP_001296943.1
ProteinModelPortal	P0A8W2
SMR	P0A8W2
BioGrid	4262957
STRING	316385.ECDH10B_1776
jPOST	P0A8W2
PaxDb	P0A8W2
PRIDE	P0A8W2
EnsemblBacteria	AAC74714 BAA15403
GeneID	946167
KEGG	ecj:JW5267 eco:b1642
PATRIC	fig|1411691.4.peg.618
EchoBASE	EB3184
EcoGene	EG13408
eggNOG	ENOG4108US0 COG1846
HOGENOM	HOG000221454
InParanoid	P0A8W2
KO	K06075
PhylomeDB	P0A8W2
BioCyc	EcoCyc:G6882-MONOMER ECOL316407:JW5267-MONOMER
PRO	PR:P0A8W2
Proteomes	UP000000318 UP000000625
GO	GO:0003677 GO:0003700 GO:2000143 GO:0009405 GO:2000144
Gene3D	1.10.10.10
HAMAP	MF_01819
InterPro	IPR000835 IPR023187 IPR023071 IPR036388 IPR036390
Pfam	PF01047
PRINTS	PR00598
SMART	SM00347
SUPFAM	SSF46785
PROSITE	PS01117 PS50995

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17892462	ECO:0001204	in vitro transcription assay evidence used in manual assertion		P		Figure 5 shows the results of an In vitro transcription assay in which 20 ng of linearized pGS1886 DNA was incubated with RNA polymerase (RNAP) and differing amounts of H-NS and SlyA. H-NS is shown to inhibit transcription of hlyE in Figure 5C through use of a PCR-amplified DNA fragment extending from −474 to +222 that includes the hlyE promoter, seemingly completely inhibiting it at H-NS concentration of 4.0 μM. Figure 5D shows that transcription can be restored by increasing concentrations of SlyA through using the same In vitro transcription assay process and 2.0 μM of H-NS. At about 1.0 μM of SlyA, hlyE appears to be transcribed at similar levels to the control, containing no H-NS. From this it can be concluded that H-NS represses hlyE transcription, and SlyA derepresses hlyE transcription. Therefore, SlyA positively regulates transcription of hlyE.	complete CACAO 13659
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21768111	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000144	positive regulation of DNA-templated transcription, initiation	PMID:28073397	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000143	negative regulation of DNA-templated transcription, initiation	PMID:28073397	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000835	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000835	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000057598	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000057598	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000057598	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P		Seeded From UniProt	complete
edit table

References

See Help:References for how to manage references in GONUTS.