GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
ECOLI:RUTA
Contents
Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
Gene Name(s) | rutA (synonyms: ycdM) | |
Protein Name(s) | Pyrimidine monooxygenase RutA | |
External Links | ||
UniProt | P75898 | |
EMBL | U00096 AP009048 | |
PIR | B64843 | |
RefSeq | NP_415532.3 YP_489285.1 | |
ProteinModelPortal | P75898 | |
SMR | P75898 | |
IntAct | P75898 | |
STRING | 511145.b1012 | |
EnsemblBacteria | AAC74097 BAA35789 | |
GeneID | 12931044 945643 | |
KEGG | ecj:Y75_p0985 eco:b1012 | |
PATRIC | 32117253 | |
EchoBASE | EB3619 | |
EcoGene | EG13859 | |
eggNOG | COG2141 | |
HOGENOM | HOG000268769 | |
InParanoid | P75898 | |
KO | K09018 | |
OMA | ADYNFCF | |
OrthoDB | EOG6RNQ9G | |
PhylomeDB | P75898 | |
BioCyc | EcoCyc:G6523-MONOMER ECOL316407:JW0997-MONOMER MetaCyc:G6523-MONOMER | |
PRO | PR:P75898 | |
Proteomes | UP000000318 UP000000625 | |
Genevestigator | P75898 | |
GO | GO:0004497 GO:0016705 GO:0052614 GO:0019740 GO:0006208 GO:0006210 GO:0006212 | |
Gene3D | 3.20.20.30 | |
HAMAP | MF_01699 | |
InterPro | IPR011251 IPR019914 | |
Pfam | PF00296 | |
SUPFAM | SSF51679 | |
TIGRFAMs | TIGR03612 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0052614 |
uracil oxygenase activity |
ECO:0000314 |
F |
Figure 3. shows NMR evidence that RutA cleaves uracil between N-3 and C-4 and incorporates oxygen from molecular oxygen. |
complete | |||||
GO:0006212 |
uracil catabolic process |
ECO:0000314 |
P |
Figure 2B. shows the disappearance of 14C-labeled uracil at the C-2 and C-6 positions due to action by RutA. The product of RutA is at a different position on the TLC plate compared with the substrate uracil. |
complete | |||||
GO:0006210 |
thymine catabolic process |
ECO:0000314 |
P |
Figure 2C. shows the disappearance of 14C-labeled thymine at the C-2 and C-6 positions due to action by RutA. The product of RutA is at a different location on the TLC plate compared with the thymine substrate. |
complete | |||||
enables |
GO:0052614 |
uracil oxygenase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006212 |
uracil catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006210 |
thymine catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019740 |
nitrogen utilization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006212 |
uracil catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0052614 |
uracil oxygenase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019740 |
nitrogen utilization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006212 |
uracil catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006208 |
pyrimidine nucleobase catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006212 |
uracil catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000084167 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006212 |
uracil catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000084167 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019740 |
nitrogen utilization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000084167 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Kim, KS et al. (2010) The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems. J. Bacteriol. 192 4089-102 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Loh, KD et al. (2006) A previously undescribed pathway for pyrimidine catabolism. Proc. Natl. Acad. Sci. U.S.A. 103 5114-9 PubMed GONUTS page
- ↑ Mukherjee, T et al. (2010) Catalysis of a flavoenzyme-mediated amide hydrolysis. J. Am. Chem. Soc. 132 5550-1 PubMed GONUTS page