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ECOLI:RSMA
Contents
| Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
| Gene Name(s) | rsmA (synonyms: ksgA) | |
| Protein Name(s) | Ribosomal RNA small subunit methyltransferase A
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase 16S rRNA dimethyladenosine transferase 16S rRNA dimethylase High level kasugamycin resistance protein KsgA Kasugamycin dimethyltransferase S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase | |
| External Links | ||
| UniProt | P06992 | |
| EMBL | M11054 X04711 U00096 AP009048 M68521 X06536 | |
| PIR | A24527 | |
| RefSeq | NP_414593.1 YP_488357.1 | |
| PDB | 1QYR 3TPZ 4ADV | |
| PDBsum | 1QYR 3TPZ 4ADV | |
| ProteinModelPortal | P06992 | |
| SMR | P06992 | |
| IntAct | P06992 | |
| MINT | MINT-1246440 | |
| STRING | 511145.b0051 | |
| PaxDb | P06992 | |
| PRIDE | P06992 | |
| EnsemblBacteria | AAC73162 BAE76038 | |
| GeneID | 12932018 944939 | |
| KEGG | ecj:Y75_p0051 eco:b0051 | |
| PATRIC | 32115201 | |
| EchoBASE | EB0518 | |
| EcoGene | EG10523 | |
| eggNOG | COG0030 | |
| HOGENOM | HOG000227962 | |
| InParanoid | P06992 | |
| KO | K02528 | |
| OMA | DHVMVEI | |
| OrthoDB | EOG66F08Z | |
| PhylomeDB | P06992 | |
| BioCyc | EcoCyc:EG10523-MONOMER ECOL316407:JW0050-MONOMER MetaCyc:EG10523-MONOMER | |
| BRENDA | 2.1.1.48 | |
| EvolutionaryTrace | P06992 | |
| PRO | PR:P06992 | |
| Proteomes | UP000000318 UP000000625 | |
| Genevestigator | P06992 | |
| GO | GO:0005737 GO:0052908 GO:0003690 GO:0003729 GO:0000179 GO:0019843 GO:0046677 GO:0000028 GO:0070475 GO:0006364 | |
| Gene3D | 1.10.8.100 3.40.50.150 | |
| HAMAP | MF_00607 | |
| InterPro | IPR001737 IPR023165 IPR020596 IPR020598 IPR011530 IPR029063 | |
| PANTHER | PTHR11727 | |
| Pfam | PF00398 | |
| SMART | SM00650 | |
| SUPFAM | SSF53335 | |
| TIGRFAMs | TIGR00755 | |
| PROSITE | PS01131 PS51689 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0019104 |
DNA N-glycosylase activity |
PMID:PMC2673420 |
ECO:0000314 |
F |
Figure 5 shows cleavage of nucleotides on miss-paired bases when KsgA is added. |
complete | ||||
|
involved_in |
GO:0031167 |
rRNA methylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000197843 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000179 |
rRNA (adenine-N6,N6-)-dimethyltransferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10523 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070475 |
rRNA base methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019843 |
rRNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006364 |
rRNA processing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003690 |
double-stranded DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000179 |
rRNA (adenine-N6,N6-)-dimethyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000028 |
ribosomal small subunit assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000154 |
rRNA modification |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000179 |
rRNA (adenine-N6,N6-)-dimethyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006364 |
rRNA processing |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008649 |
rRNA methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052908 |
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000154 |
rRNA modification |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000098205 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000098205 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016433 |
rRNA (adenine) methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000098205 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006364 |
rRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046677 |
response to antibiotic |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Zimmermann, RA et al. (1973) Alteration of ribosomal protein S4 by mutation linked to kasugamycin-resistance in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 70 71-5 PubMed GONUTS page
- ↑ 3.0 3.1 van Gemen, B et al. (1989) Autogenous regulation of the Escherichia coli ksgA gene at the level of translation. J. Bacteriol. 171 4002-8 PubMed GONUTS page
- ↑ 4.0 4.1 Connolly, K et al. (2008) Mechanistic insight into the ribosome biogenesis functions of the ancient protein KsgA. Mol. Microbiol. 70 1062-75 PubMed GONUTS page
- ↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
- ↑ Inoue, K et al. (2007) Dissection of 16S rRNA methyltransferase (KsgA) function in Escherichia coli. J. Bacteriol. 189 8510-8 PubMed GONUTS page
- ↑ Poldermans, B et al. (1979) Studies on the function of two adjacent N6,N6-dimethyladenosines near the 3' end of 16 S ribosomal RNA of Escherichia coli. III. Purification and properties of the methylating enzyme and methylase-30 S interactions. J. Biol. Chem. 254 9094-100 PubMed GONUTS page
b
r
- GO:0046677 ! response to antibiotic
- GO:0000028 ! ribosomal small subunit assembly
- GO:0003723 ! RNA binding
- GO:0016433 ! rRNA (adenine) methyltransferase activity
- GO:0000179 ! rRNA (adenine-N6,N6-)-dimethyltransferase activity
- GO:0070475 ! rRNA base methylation
- GO:0019843 ! rRNA binding
- GO:0031167 ! rRNA methylation
- GO:0008649 ! rRNA methyltransferase activity
- GO:0000154 ! rRNA modification
- GO:0006364 ! rRNA processing
