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ECOLI:RLUA

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) rluA (synonyms: yabO)
Protein Name(s) Ribosomal large subunit pseudouridine synthase A

23S rRNA pseudouridine(746) synthase rRNA pseudouridylate synthase A rRNA-uridine isomerase A tRNA pseudouridine(32) synthase

External Links
UniProt P0AA37
EMBL U00096
AP009048
PIR B64727
RefSeq NP_414600.1
YP_488364.1
PDB 2I82
PDBsum 2I82
ProteinModelPortal P0AA37
SMR P0AA37
DIP DIP-47988N
IntAct P0AA37
STRING 511145.b0058
PaxDb P0AA37
PRIDE P0AA37
EnsemblBacteria AAC73169
BAE76039
GeneID 12933046
946262
KEGG ecj:Y75_p0058
eco:b0058
PATRIC 32115215
EchoBASE EB2493
EcoGene EG12609
eggNOG COG0564
HOGENOM HOG000275919
InParanoid P0AA37
KO K06177
OMA EKYGFCE
OrthoDB EOG6P070X
PhylomeDB P0AA37
BioCyc EcoCyc:EG12609-MONOMER
ECOL316407:JW0057-MONOMER
MetaCyc:EG12609-MONOMER
EvolutionaryTrace P0AA37
PRO PR:P0AA37
Proteomes UP000000318
UP000000625
Genevestigator P0AA37
GO GO:0009982
GO:0003723
GO:0000455
GO:0001522
GO:0009451
GO:0006364
GO:0031118
GO:0008033
GO:0031119
InterPro IPR020103
IPR006225
IPR006224
IPR006145
Pfam PF00849
SUPFAM SSF55120
TIGRFAMs TIGR00005
PROSITE PS01129

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0031119

tRNA pseudouridine synthesis

PMID:10383384[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031118

rRNA pseudouridine synthesis

PMID:10383384[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0009982

pseudouridine synthase activity

PMID:10383384[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009451

RNA modification

PMID:10383384[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008033

tRNA processing

PMID:10383384[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006364

rRNA processing

PMID:10383384[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001522

pseudouridine synthesis

PMID:10383384[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031119

tRNA pseudouridine synthesis

PMID:10383384[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0009982

pseudouridine synthase activity

PMID:7493321[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000455

enzyme-directed rRNA pseudouridine synthesis

PMID:10383384[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001522

pseudouridine synthesis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006145
InterPro:IPR006224
InterPro:IPR006225
InterPro:IPR020103

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006145
InterPro:IPR006224
InterPro:IPR006225
InterPro:IPR020103

F

Seeded From UniProt

complete

involved_in

GO:0009451

RNA modification

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006145
InterPro:IPR006224
InterPro:IPR006225
InterPro:IPR020103

P

Seeded From UniProt

complete

enables

GO:0009982

pseudouridine synthase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006145
InterPro:IPR006224
InterPro:IPR006225
InterPro:IPR020103

F

Seeded From UniProt

complete

enables

GO:0106029

tRNA pseudouridine synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:5.4.99.28

F

Seeded From UniProt

complete

enables

GO:0120159

rRNA pseudouridine synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:5.4.99.29

F

Seeded From UniProt

complete

involved_in

GO:0008033

tRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0819

P

Seeded From UniProt

complete

involved_in

GO:0006364

rRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0698

P

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0413

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Raychaudhuri, S et al. (1999) Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA. J. Biol. Chem. 274 18880-6 PubMed GONUTS page
  2. Wrzesinski, J et al. (1995) A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for psi 746 in 23S RNA is also specific for psi 32 in tRNA(phe). RNA 1 437-48 PubMed GONUTS page