GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
ECOLI:PURK
Contents
| Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
| Gene Name(s) | purK (ECO:0000255 with HAMAP-Rule:MF_01928) | |
| Protein Name(s) | N5-carboxyaminoimidazole ribonucleotide synthase (ECO:0000255 with HAMAP-Rule:MF_01928, ECO:0000305)
N5-CAIR synthase (ECO:0000255 with HAMAP-Rule:MF_01928, ECO:0000305) 5-(carboxyamino)imidazole ribonucleotide synthetase (ECO:0000255 with HAMAP-Rule:MF_01928, ECO:0000305) | |
| External Links | ||
| UniProt | P09029 | |
| EMBL | X12982 M19657 U82664 U00096 AP009048 | |
| PIR | JU0001 | |
| RefSeq | NP_415055.1 YP_488811.1 | |
| PDB | 1B6R 1B6S 3ETH 3ETJ | |
| PDBsum | 1B6R 1B6S 3ETH 3ETJ | |
| ProteinModelPortal | P09029 | |
| SMR | P09029 | |
| IntAct | P09029 | |
| STRING | 511145.b0522 | |
| SWISS-2DPAGE | P09029 | |
| PaxDb | P09029 | |
| PRIDE | P09029 | |
| EnsemblBacteria | AAC73624 BAE76299 | |
| GeneID | 12930881 945153 | |
| KEGG | ecj:Y75_p0508 eco:b0522 | |
| PATRIC | 32116204 | |
| EchoBASE | EB0789 | |
| EcoGene | EG10796 | |
| eggNOG | COG0026 | |
| HOGENOM | HOG000034026 | |
| InParanoid | P09029 | |
| KO | K01589 | |
| OMA | WYGKEKR | |
| OrthoDB | EOG6QZMX7 | |
| PhylomeDB | P09029 | |
| BioCyc | EcoCyc:PURK-MONOMER ECOL316407:JW0511-MONOMER MetaCyc:PURK-MONOMER | |
| UniPathway | UPA00074 | |
| EvolutionaryTrace | P09029 | |
| PRO | PR:P09029 | |
| Proteomes | UP000000318 UP000000625 | |
| Genevestigator | P09029 | |
| GO | GO:0034028 GO:0005524 GO:0046872 GO:0004638 GO:0006189 | |
| Gene3D | 3.30.470.20 3.40.50.20 | |
| HAMAP | MF_01928 | |
| InterPro | IPR005875 IPR011761 IPR003135 IPR013816 IPR016185 IPR011054 | |
| Pfam | PF02222 | |
| SUPFAM | SSF51246 SSF52440 | |
| TIGRFAMs | TIGR01161 | |
| PROSITE | PS50975 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004638 |
phosphoribosylaminoimidazole carboxylase activity |
ECO:0000314 |
F |
Figure 6. NMR analysis demonstrates that PurK converts AIR to N5-CAIR as part of a direct assay. |
complete | |||||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10796 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004638 |
phosphoribosylaminoimidazole carboxylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034028 |
5-(carboxyamino)imidazole ribonucleotide synthase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004638 |
phosphoribosylaminoimidazole carboxylase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006189 |
'de novo' IMP biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034028 |
5-(carboxyamino)imidazole ribonucleotide synthase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034028 |
5-(carboxyamino)imidazole ribonucleotide synthase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000161642 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006189 |
'de novo' IMP biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000161642 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006164 |
purine nucleotide biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016874 |
ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006189 |
'de novo' IMP biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00074 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Mueller, EJ et al. (1994) N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli. Biochemistry 33 2269-78 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
- ↑ Thoden, JB et al. (2008) Structural analysis of the active site geometry of N5-carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli. Biochemistry 47 13346-53 PubMed GONUTS page
b
