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ECOLI:PUR9

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) purH
Protein Name(s) Bifunctional purine biosynthesis protein PurH

Phosphoribosylaminoimidazolecarboxamide formyltransferase AICAR transformylase IMP cyclohydrolase ATIC IMP synthase Inosinicase

External Links
UniProt P15639
EMBL J05126
X51950
U00006
U00096
AP009048
PIR B34193
RefSeq NP_418434.1
YP_491454.1
ProteinModelPortal P15639
SMR P15639
IntAct P15639
STRING 511145.b4006
SWISS-2DPAGE P15639
PaxDb P15639
PRIDE P15639
EnsemblBacteria AAC76980
BAE77313
GeneID 12933467
948503
KEGG ecj:Y75_p3190
eco:b4006
PATRIC 32123537
EchoBASE EB0788
EcoGene EG10795
eggNOG COG0138
HOGENOM HOG000230372
InParanoid P15639
KO K00602
OMA PCGVAEG
OrthoDB EOG6QCDFF
PhylomeDB P15639
BioCyc EcoCyc:AICARTRANSIMPCYCLO-CPLX
ECOL316407:JW3970-MONOMER
MetaCyc:AICARTRANSIMPCYCLO-CPLX
UniPathway UPA00074
UPA00074
PRO PR:P15639
Proteomes UP000000318
UP000000625
Genevestigator P15639
GO GO:0003937
GO:0004643
GO:0006189
GO:0042710
Gene3D 3.40.140.20
3.40.50.1380
HAMAP MF_00139
InterPro IPR024051
IPR002695
IPR016193
IPR011607
PANTHER PTHR11692
Pfam PF01808
PF02142
PIRSF PIRSF000414
SMART SM00798
SM00851
SUPFAM SSF52335
SSF53927
TIGRFAMs TIGR00355

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0042710

biofilm formation

PMID:22359582[1]

ECO:0000315

P

Figure 4A. shows lack of Congo red binding by strains deficient in purH deletion mutant.

Figure 4B. shows a significant reduction of csgDEFG transcript levels in purH mutant. csgDEFG are genes encoding proteins responsible for curli assembly and transport.

complete
CACAO 5390

part_of

GO:0005829

cytosol

PMID:18304323[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15911532[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016193

F

Seeded From UniProt

complete

enables

GO:0003937

IMP cyclohydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002695

F

Seeded From UniProt

complete

enables

GO:0004643

phosphoribosylaminoimidazolecarboxamide formyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002695

F

Seeded From UniProt

complete

involved_in

GO:0006164

purine nucleotide biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002695

P

Seeded From UniProt

complete

enables

GO:0003937

IMP cyclohydrolase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.4.10

F

Seeded From UniProt

complete

enables

GO:0004643

phosphoribosylaminoimidazolecarboxamide formyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.2.3

F

Seeded From UniProt

complete

involved_in

GO:0006189

'de novo' IMP biosynthetic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000078535

P

Seeded From UniProt

complete

enables

GO:0004643

phosphoribosylaminoimidazolecarboxamide formyltransferase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000078535

F

Seeded From UniProt

complete

enables

GO:0003937

IMP cyclohydrolase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000078535

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

involved_in

GO:0006164

purine nucleotide biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0658

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

involved_in

GO:0006189

'de novo' IMP biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00074

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Garavaglia, M et al. (2012) The pyrimidine nucleotide biosynthetic pathway modulates production of biofilm determinants in Escherichia coli. PLoS ONE 7 e31252 PubMed GONUTS page
  2. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
  3. Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page