ECOLI:PTND

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	manZ (synonyms: gptB, ptsM)
Protein Name(s)	Mannose permease IID component EII-M-Man EIID-Man PTS system mannose-specific EIID component
External Links
UniProt	P69805
EMBL	J02699 U00096 AP009048
PIR	A30288
RefSeq	NP_416333.4 YP_490080.1
IntAct	P69805
STRING	511145.b1819
TCDB	4.A.6.1.1
PaxDb	P69805
EnsemblBacteria	AAC74889 BAA15631
GeneID	12930152 946342
KEGG	ecj:Y75_p1794 eco:b1819
PATRIC	32118957
EchoBASE	EB0564
EcoGene	EG10569
eggNOG	COG3716
HOGENOM	HOG000098670
InParanoid	P69805
KO	K02796
BioCyc	EcoCyc:MANZ-MONOMER ECOL316407:JW1808-MONOMER MetaCyc:MANZ-MONOMER
PRO	PR:P69805
Proteomes	UP000000318 UP000000625
Genevestigator	P69805
GO	GO:0005887 GO:0016020 GO:0022870 GO:0015761 GO:0009401
InterPro	IPR004704 IPR018405
PANTHER	PTHR32502:SF5
Pfam	PF03613
TIGRFAMs	TIGR00828
PROSITE	PS51108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005887	integral to plasma membrane	PMID:8774730^[1]	ECO:0000255		PMID:7108955^[2]	C	Fig. 1B shows the hydropathy plot of the protein, indicating it is located in the plasma membrane.	complete CACAO 8777
part_of	GO:0005887	integral component of plasma membrane	PMID:8774730^[1]	ECO:0000255	match to sequence model evidence used in manual assertion		C	Seeded From UniProt	Missing: with/from
part_of	GO:0016020	membrane	PMID:16858726^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009401	phosphoenolpyruvate-dependent sugar phosphotransferase system	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10568 EcoGene:EG10569 PANTHER:PTN000789828	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10568 EcoGene:EG10569 PANTHER:PTN000789828	C	Seeded From UniProt	complete
involved_in	GO:0098708	glucose import across plasma membrane	PMID:5545083^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0022870	protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity	PMID:2999119^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0015761	mannose transmembrane transport	PMID:5545083^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009401	phosphoenolpyruvate-dependent sugar phosphotransferase system	PMID:2999119^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:2999119^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17309111^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15919996^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009401	phosphoenolpyruvate-dependent sugar phosphotransferase system	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004704	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004704	C	Seeded From UniProt	complete
involved_in	GO:0009401	phosphoenolpyruvate-dependent sugar phosphotransferase system	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0598	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0997 UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0037	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0008643	carbohydrate transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0762	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Huber, F & Erni, B (1996) Membrane topology of the mannose transporter of Escherichia coli K12. Eur. J. Biochem. 239 810-7 PubMed GONUTS page
↑ Kyte, J & Doolittle, RF (1982) A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157 105-32 PubMed GONUTS page
↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed GONUTS page
↑ ^4.0 ^4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Kundig, W & Roseman, S (1971) Sugar transport. II. Characterization of constitutive membrane-bound enzymes II of the Escherichia coli phosphotransferase system. J. Biol. Chem. 246 1407-18 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Erni, B & Zanolari, B (1985) The mannose-permease of the bacterial phosphotransferase system. Gene cloning and purification of the enzyme IIMan/IIIMan complex of Escherichia coli. J. Biol. Chem. 260 15495-503 PubMed GONUTS page
↑ Zhang, N et al. (2007) Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Proteomics 7 484-93 PubMed GONUTS page
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page

[PMID:8774730-1] 1.0 ^1.1 Huber, F & Erni, B (1996) Membrane topology of the mannose transporter of Escherichia coli K12. Eur. J. Biochem. 239 810-7 PubMed GONUTS page

[PMID:7108955-2] Kyte, J & Doolittle, RF (1982) A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157 105-32 PubMed GONUTS page

[PMID:16858726-3] Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:5545083-5] 5.0 ^5.1 Kundig, W & Roseman, S (1971) Sugar transport. II. Characterization of constitutive membrane-bound enzymes II of the Escherichia coli phosphotransferase system. J. Biol. Chem. 246 1407-18 PubMed GONUTS page

[PMID:2999119-6] 6.0 ^6.1 ^6.2 Erni, B & Zanolari, B (1985) The mannose-permease of the bacterial phosphotransferase system. Gene cloning and purification of the enzyme IIMan/IIIMan complex of Escherichia coli. J. Biol. Chem. 260 15495-503 PubMed GONUTS page

[PMID:17309111-7] Zhang, N et al. (2007) Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Proteomics 7 484-93 PubMed GONUTS page

[PMID:15919996-8] Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page

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ECOLI:PTND

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