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ECOLI:PANE

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) panE (synonyms: apbA)
Protein Name(s) 2-dehydropantoate 2-reductase

Ketopantoate reductase KPA reductase KPR

External Links
UniProt P0A9J4
EMBL U82664
U00096
AP009048
U34923
PIR A64772
RefSeq NP_414959.1
YP_488717.1
PDB 1KS9
1YJQ
1YON
2OFP
PDBsum 1KS9
1YJQ
1YON
2OFP
ProteinModelPortal P0A9J4
SMR P0A9J4
IntAct P0A9J4
STRING 511145.b0425
BindingDB P0A9J4
ChEMBL CHEMBL4855
PRIDE P0A9J4
EnsemblBacteria AAC73528
BAE76205
GeneID 12933987
945065
KEGG ecj:Y75_p0413
eco:b0425
PATRIC 32116001
EchoBASE EB3056
EcoGene EG13271
eggNOG COG1893
HOGENOM HOG000050223
InParanoid P0A9J4
KO K00077
OMA WKWAKAI
OrthoDB EOG68SVW3
PhylomeDB P0A9J4
BioCyc EcoCyc:2-DEHYDROPANTOATE-REDUCT-MONOMER
ECOL316407:JW0415-MONOMER
MetaCyc:2-DEHYDROPANTOATE-REDUCT-MONOMER
SABIO-RK P0A9J4
UniPathway UPA00028
EvolutionaryTrace P0A9J4
PRO PR:P0A9J4
Proteomes UP000000318
UP000000625
Genevestigator P0A9J4
GO GO:0005737
GO:0008677
GO:0050661
GO:0033317
Gene3D 1.10.1040.10
3.40.50.720
InterPro IPR008927
IPR003710
IPR013328
IPR013752
IPR013332
IPR016040
Pfam PF02558
PF08546
SUPFAM SSF48179
TIGRFAMs TIGR00745

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0050661

NADP binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13271
PANTHER:PTN002464833

F

Seeded From UniProt

complete

involved_in

GO:0033317

pantothenate biosynthetic process from valine

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13271
PANTHER:PTN002464833

P

Seeded From UniProt

complete

enables

GO:0008677

2-dehydropantoate 2-reductase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13271
PANTHER:PTN002464833

F

Seeded From UniProt

complete

enables

GO:0050661

NADP binding

PMID:10736170[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0033317

pantothenate biosynthetic process from valine

PMID:10553653[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008677

2-dehydropantoate 2-reductase activity

PMID:10736170[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008677

2-dehydropantoate 2-reductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003710

F

Seeded From UniProt

complete

involved_in

GO:0015940

pantothenate biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003710

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013328

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008927
InterPro:IPR013328

P

Seeded From UniProt

complete

enables

GO:0008677

2-dehydropantoate 2-reductase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.169

F

Seeded From UniProt

complete

involved_in

GO:0015940

pantothenate biosynthetic process

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0566
UniPathway:UPA00028

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. 2.0 2.1 Zheng, R & Blanchard, JS (2000) Kinetic and mechanistic analysis of the E. coli panE-encoded ketopantoate reductase. Biochemistry 39 3708-17 PubMed GONUTS page
  3. Elischewski, F et al. (1999) Pantothenate production in Escherichia coli K12 by enhanced expression of the panE gene encoding ketopantoate reductase. J. Biotechnol. 75 135-46 PubMed GONUTS page