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ECOLI:NARL

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) narL (synonyms: frdR)
Protein Name(s) Nitrate/nitrite response regulator protein NarL
External Links
UniProt P0AF28
EMBL X13360
M24910
X14884
X69189
U00096
AP009048
PIR S09285
RefSeq NP_415739.1
YP_489491.1
PDB 1A04
1JE8
1RNL
1ZG1
1ZG5
PDBsum 1A04
1JE8
1RNL
1ZG1
1ZG5
ProteinModelPortal P0AF28
SMR P0AF28
DIP DIP-35941N
IntAct P0AF28
STRING 511145.b1221
PaxDb P0AF28
PRIDE P0AF28
EnsemblBacteria AAC74305
BAA36089
GeneID 12932638
945795
KEGG ecj:Y75_p1196
eco:b1221
PATRIC 32117700
EchoBASE EB0637
EcoGene EG10643
eggNOG COG2197
HOGENOM HOG000034813
InParanoid P0AF28
KO K07684
OMA NTSRPAY
OrthoDB EOG69GZGV
PhylomeDB P0AF28
BioCyc EcoCyc:NARL-MONOMER
ECOL316407:JW1212-MONOMER
EvolutionaryTrace P0AF28
PRO PR:P0AF28
Proteomes UP000000318
UP000000625
Genevestigator P0AF28
GO GO:0005524
GO:0003677
GO:0003700
GO:0042128
GO:0000160
GO:0010468
GO:0090352
GO:0006355
GO:0006351
Gene3D 1.10.10.10
InterPro IPR011006
IPR016032
IPR001789
IPR000792
IPR011991
Pfam PF00196
PF00072
PRINTS PR00038
SMART SM00421
SM00448
SUPFAM SSF46894
SSF52172
PROSITE PS00622
PS50043
PS50110

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006355

regulation of transcription, DNA-dependent

PMID:20634237[1]

ECO:0000315

P

Table 4: shows the regulation ability of NarL mutants in activating sigma factor transcription

complete

part_of

GO:0032993

protein-DNA complex

PMID:19251855[2]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_000913.2

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:19251855[2]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001217

DNA-binding transcription repressor activity

PMID:19251855[2]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_000913.2

F

Seeded From UniProt

complete

enables

GO:0001217

DNA-binding transcription repressor activity

PMID:19251855[2]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:19251855[2]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_000913.2

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:19251855[2]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0090352

regulation of nitrate assimilation

PMID:2066339[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010468

regulation of gene expression

PMID:16199562[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:7854119[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:7854119[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001217

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001217

P

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001789

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016032

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000792
InterPro:IPR016032

P

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0902

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0042128

nitrate assimilation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0534

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Lin, AV & Stewart, V (2010) Functional roles for the GerE-family carboxyl-terminal domains of nitrate response regulators NarL and NarP of Escherichia coli K-12. Microbiology (Reading, Engl.) 156 2933-43 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Xu, M et al. (2009) Activation and repression at the Escherichia coli ynfEFGHI operon promoter. J. Bacteriol. 191 3172-6 PubMed GONUTS page
  3. Egan, SM & Stewart, V (1991) Mutational analysis of nitrate regulatory gene narL in Escherichia coli K-12. J. Bacteriol. 173 4424-32 PubMed GONUTS page
  4. Stewart, V & Bledsoe, PJ (2005) Fnr-, NarP- and NarL-dependent regulation of transcription initiation from the Haemophilus influenzae Rd napF (periplasmic nitrate reductase) promoter in Escherichia coli K-12. J. Bacteriol. 187 6928-35 PubMed GONUTS page
  5. 5.0 5.1 Tyson, KL et al. (1994) Nitrite and nitrate regulation at the promoters of two Escherichia coli operons encoding nitrite reductase: identification of common target heptamers for both NarP- and NarL-dependent regulation. Mol. Microbiol. 13 1045-55 PubMed GONUTS page
  6. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page