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ECOLI:NADR

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) nadR (synonyms: nadI)
Protein Name(s) Trifunctional NAD biosynthesis/regulator protein NadR

Transcriptional regulator NadR Nicotinamide mononucleotide adenylyltransferase NMN adenylyltransferase NMN-AT NMNAT Nicotinamide ribonucleotide adenylyltransferase Nicotinamide-nucleotide adenylyltransferase Ribosylnicotinamide kinase RNK Nicotinamide riboside kinase NRK NmR-K

External Links
UniProt P27278
EMBL U14003
U00096
AP009048
X63155
PIR S56614
RefSeq NP_418807.4
YP_492520.1
ProteinModelPortal P27278
SMR P27278
STRING 511145.b4390
PaxDb P27278
PRIDE P27278
EnsemblBacteria AAC77343
BAE78379
GeneID 12931806
948911
KEGG ecj:Y75_p4274
eco:b4390
PATRIC 32124396
EchoBASE EB1311
EcoGene EG11335
eggNOG COG3172
HOGENOM HOG000127874
InParanoid P27278
KO K06211
OMA QIRQDPF
OrthoDB EOG6P06X5
BioCyc EcoCyc:PD04413
ECOL316407:JW5800-MONOMER
MetaCyc:PD04413
UniPathway UPA00253
UPA00253
PRO PR:P27278
Proteomes UP000000318
UP000000625
Genevestigator P27278
GO GO:0005737
GO:0005886
GO:0005524
GO:0000986
GO:0000287
GO:0000309
GO:0050262
GO:0009435
GO:0045892
GO:0006351
GO:0006810
Gene3D 1.10.260.40
3.40.50.300
3.40.50.620
InterPro IPR016429
IPR001387
IPR004821
IPR010982
IPR006417
IPR027417
IPR014729
Pfam PF01381
PIRSF PIRSF004776
SMART SM00530
SUPFAM SSF47413
SSF52540
TIGRFAMs TIGR00125
TIGR01526
PROSITE PS50943

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0071248

cellular response to metal ion

PMID:10464228[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051289

protein homotetramerization

PMID:10464228[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:10464228[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010446

response to alkaline pH

PMID:10464228[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009435

NAD biosynthetic process

PMID:10464228[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000309

nicotinamide-nucleotide adenylyltransferase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11335
PANTHER:PTN002206349
UniProtKB:P44308

F

Seeded From UniProt

complete

enables

GO:0000986

bacterial-type proximal promoter sequence-specific DNA binding

PMID:10464228[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000309

nicotinamide-nucleotide adenylyltransferase activity

PMID:10464228[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

PMID:10464228[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000309

nicotinamide-nucleotide adenylyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006417

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010982

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004821

F

Seeded From UniProt

complete

involved_in

GO:0009058

biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004821

P

Seeded From UniProt

complete

involved_in

GO:0009435

NAD biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006417

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001387

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016429

P

Seeded From UniProt

complete

enables

GO:0000309

nicotinamide-nucleotide adenylyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.7.1

F

Seeded From UniProt

complete

enables

GO:0050262

ribosylnicotinamide kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.1.22

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

involved_in

GO:0019363

pyridine nucleotide biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0662

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0009435

NAD biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00253

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Raffaelli, N et al. (1999) The Escherichia coli NadR regulator is endowed with nicotinamide mononucleotide adenylyltransferase activity. J. Bacteriol. 181 5509-11 PubMed GONUTS page
  2. Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page