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ECOLI:MEPS

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) mepS (synonyms: spr, yeiV)
Protein Name(s) Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase

Lipoprotein Spr Murein hydrolase MepS

External Links
UniProt P0AFV4
EMBL D86610
U00096
AP009048
PIR F64986
RefSeq NP_416680.1
WP_000241011.1
PDB 2K1G
PDBsum 2K1G
ProteinModelPortal P0AFV4
SMR P0AFV4
BioGrid 4261093
IntAct P0AFV4
STRING 511145.b2175
MEROPS C40.004
PaxDb P0AFV4
PRIDE P0AFV4
EnsemblBacteria AAC75236
BAA15983
GeneID 946686
KEGG ecj:JW2163
eco:b2175
PATRIC 32119705
EchoBASE EB3829
EcoGene EG14076
eggNOG ENOG4107TT5
COG0791
HOGENOM HOG000229978
InParanoid P0AFV4
KO K13694
OMA GRHIGIY
OrthoDB EOG60CWQW
PhylomeDB P0AFV4
BioCyc EcoCyc:G7147-MONOMER
ECOL316407:JW2163-MONOMER
MetaCyc:G7147-MONOMER
UniPathway UPA00963
EvolutionaryTrace P0AFV4
PRO PR:P0AFV4
Proteomes UP000000318
UP000000625
GO GO:0009279
GO:0008234
GO:0004175
GO:0045227
GO:0071555
GO:0000270
GO:0009254
Gene3D 3.90.1720.10
InterPro IPR000064
Pfam PF00877
PROSITE PS51257

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009254

peptidoglycan turnover

PMID:23062283[1]

ECO:0000315

P

Fig 2, Fig 5 C & D, Fig 6

complete
CACAO 5429

involved_in

GO:0009254

peptidoglycan turnover

PMID:23062283[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009279

cell outer membrane

PMID:18715016[2]

ECO:0000245

automatically integrated combinatorial evidence used in manual assertion

Pfam:PF00877

C

Seeded From UniProt

complete

enables

GO:0004175

endopeptidase activity

PMID:23062283[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004175

endopeptidase activity

PMID:12620121[3]

ECO:0000245

automatically integrated combinatorial evidence used in manual assertion

Pfam:PF00877

F

Seeded From UniProt

complete

involved_in

GO:0000270

peptidoglycan metabolic process

PMID:23062283[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009279

cell outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0998
UniProtKB-SubCell:SL-0040

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0788

F

Seeded From UniProt

complete

involved_in

GO:0071555

cell wall organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0961

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0045227

capsule polysaccharide biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00963

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Singh, SK et al. (2012) Three redundant murein endopeptidases catalyse an essential cleavage step in peptidoglycan synthesis of Escherichia coli K12. Mol. Microbiol. 86 1036-51 PubMed GONUTS page
  2. Aramini, JM et al. (2008) Solution NMR structure of the NlpC/P60 domain of lipoprotein Spr from Escherichia coli: structural evidence for a novel cysteine peptidase catalytic triad. Biochemistry 47 9715-7 PubMed GONUTS page
  3. Anantharaman, V & Aravind, L (2003) Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes. Genome Biol. 4 R11 PubMed GONUTS page