ECOLI:LRP

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	lrp (synonyms: alsB, ihb, livR, oppI)
Protein Name(s)	Leucine-responsive regulatory protein
External Links
UniProt	P0ACJ0
EMBL	M35869 D11105 U00096 AP009048
PIR	JH0412
RefSeq	NP_415409.1 YP_489161.1
PDB	2GQQ 2L4A
PDBsum	2GQQ 2L4A
ProteinModelPortal	P0ACJ0
SMR	P0ACJ0
DIP	DIP-35825N
IntAct	P0ACJ0
STRING	511145.b0889
PaxDb	P0ACJ0
PRIDE	P0ACJ0
EnsemblBacteria	AAC73975 BAA35614
GeneID	12931703 949051
KEGG	ecj:Y75_p0861 eco:b0889
PATRIC	32116989
EchoBASE	EB0542
EcoGene	EG10547
eggNOG	COG1522
HOGENOM	HOG000115327
InParanoid	P0ACJ0
KO	K03719
OMA	LVFVEIK
OrthoDB	EOG6F29D2
PhylomeDB	P0ACJ0
BioCyc	EcoCyc:PD00353 ECOL316407:JW0872-MONOMER
EvolutionaryTrace	P0ACJ0
PRO	PR:P0ACJ0
Proteomes	UP000000318 UP000000625
Genevestigator	P0ACJ0
GO	GO:0005622 GO:0042802 GO:0043565 GO:0003700 GO:0009098 GO:0006355 GO:0043201 GO:0006351
Gene3D	1.10.10.10 3.30.70.920
InterPro	IPR000485 IPR011008 IPR019888 IPR019887 IPR019885 IPR011991
Pfam	PF01037 PF13412
PRINTS	PR00033
SMART	SM00344
SUPFAM	SSF54909
PROSITE	PS00519 PS50956

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0010467	gene expression	PMID:8955316^[1]	ECO:0000269			P	Figure 1B indicates that the induction of of lrp expression in cells entering the stationary phase, grown in a rich medium, is not dependent on the stationary phase sigma factor encoded by rpoS	complete
	GO:0010467	gene expression	PMID:8955316^[1]	ECO:0000269			P	Table 2 illustrates that Lrp does not play any role in the stationary phase induction of the lrp gene.	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:8144448^[2]	ECO:0005657	primer extension assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:8144448^[2]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:10216857^[3]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:10216857^[3]	ECO:0005643	hydroxyl-radical footprinting evidence used in manual assertion	RefSeq:NC_000913.2	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:8144448^[2]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000913.2	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:8144448^[2]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:8144448^[2]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:10216857^[3]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:10216857^[3]	ECO:0005643	hydroxyl-radical footprinting evidence used in manual assertion	RefSeq:NC_000913.2	F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:8144448^[2]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000913.2	F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:8144448^[2]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:10216857^[3]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:10216857^[3]	ECO:0005643	hydroxyl-radical footprinting evidence used in manual assertion	RefSeq:NC_000913.2	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:8144448^[2]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:10216857^[3]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:10216857^[3]	ECO:0005643	hydroxyl-radical footprinting evidence used in manual assertion	RefSeq:NC_000913.2	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:8144448^[2]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000913.2	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:8144448^[2]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10547 PANTHER:PTN001248975	F	Seeded From UniProt	complete
involved_in	GO:0043201	response to leucine	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10547 PANTHER:PTN000765740	P	Seeded From UniProt	complete
involved_in	GO:0006524	alanine catabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000765740 UniProtKB:Q9HTP6	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10547 PANTHER:PTN001248975	C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21642464^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0ACJ0	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:10551881^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043201	response to leucine	PMID:12054800^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:12374860^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009098	leucine biosynthetic process	PMID:12054800^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18304323^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001216	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001216	P	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019888	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019888	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000485 InterPro:IPR019888	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Landgraf, JR et al. (1996) Effects of nutrition and growth rate on Lrp levels in Escherichia coli. J. Bacteriol. 178 6930-6 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Wang, Q et al. (1994) Regulation of the Escherichia coli lrp gene. J. Bacteriol. 176 1831-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Zhi, J et al. (1999) Lrp binds to two regions in the dadAX promoter region of Escherichia coli to repress and activate transcription directly. Mol. Microbiol. 32 29-40 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Hart, BR et al. (2011) Recognition of DNA by the helix-turn-helix global regulatory protein Lrp is modulated by the amino terminus. J. Bacteriol. 193 3794-803 PubMed GONUTS page
↑ Azam, TA & Ishihama, A (1999) Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J. Biol. Chem. 274 33105-13 PubMed GONUTS page
↑ ^7.0 ^7.1 Chen, S & Calvo, JM (2002) Leucine-induced dissociation of Escherichia coli Lrp hexadecamers to octamers. J. Mol. Biol. 318 1031-42 PubMed GONUTS page
↑ Tani, TH et al. (2002) Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis. Proc. Natl. Acad. Sci. U.S.A. 99 13471-6 PubMed GONUTS page
↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page

[PMID:8955316-1] 1.0 ^1.1 Landgraf, JR et al. (1996) Effects of nutrition and growth rate on Lrp levels in Escherichia coli. J. Bacteriol. 178 6930-6 PubMed GONUTS page

[PMID:8144448-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Wang, Q et al. (1994) Regulation of the Escherichia coli lrp gene. J. Bacteriol. 176 1831-9 PubMed GONUTS page

[PMID:10216857-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Zhi, J et al. (1999) Lrp binds to two regions in the dadAX promoter region of Escherichia coli to repress and activate transcription directly. Mol. Microbiol. 32 29-40 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21642464-5] Hart, BR et al. (2011) Recognition of DNA by the helix-turn-helix global regulatory protein Lrp is modulated by the amino terminus. J. Bacteriol. 193 3794-803 PubMed GONUTS page

[PMID:10551881-6] Azam, TA & Ishihama, A (1999) Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J. Biol. Chem. 274 33105-13 PubMed GONUTS page

[PMID:12054800-7] 7.0 ^7.1 Chen, S & Calvo, JM (2002) Leucine-induced dissociation of Escherichia coli Lrp hexadecamers to octamers. J. Mol. Biol. 318 1031-42 PubMed GONUTS page

[PMID:12374860-8] Tani, TH et al. (2002) Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis. Proc. Natl. Acad. Sci. U.S.A. 99 13471-6 PubMed GONUTS page

[PMID:18304323-9] Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

ECOLI:LRP

Contents

Annotations

Notes

References

a

b

c

d

e

g

i

l

n

p

r

s

t

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools