ECOLI:LPXK

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	lpxK (synonyms: ycaH)
Protein Name(s)	Tetraacyldisaccharide 4'-kinase Lipid A 4'-kinase
External Links
UniProt	P27300
EMBL	Z11796 U00096 AP009048
PIR	B64831
RefSeq	NP_415435.1 YP_489187.1
ProteinModelPortal	P27300
SMR	P27300
DIP	DIP-10126N
IntAct	P27300
STRING	511145.b0915
PaxDb	P27300
PRIDE	P27300
EnsemblBacteria	AAC74001 BAA35661
GeneID	12931020 945526
KEGG	ecj:Y75_p0887 eco:b0915
PATRIC	32117043
EchoBASE	EB1381
EcoGene	EG11409
eggNOG	COG1663
HOGENOM	HOG000004953
InParanoid	P27300
KO	K00912
OMA	PTVIYLI
OrthoDB	EOG60GRWT
PhylomeDB	P27300
BioCyc	EcoCyc:TETRAACYLDISACC4KIN-MONOMER ECOL316407:JW0898-MONOMER MetaCyc:TETRAACYLDISACC4KIN-MONOMER
UniPathway	UPA00359
PRO	PR:P27300
Proteomes	UP000000318 UP000000625
Genevestigator	P27300
GO	GO:0016020 GO:0005886 GO:0005524 GO:0016301 GO:0009029 GO:0009245 GO:0009244
Gene3D	3.40.50.300
HAMAP	MF_00409
InterPro	IPR027417 IPR003758
Pfam	PF02606
SUPFAM	SSF52540
TIGRFAMs	TIGR00682

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0016020	membrane	PMID:9268317^[1]	ECO:0000314			C	Fig.6, lanes 4&8	complete
	GO:0009029	tetraacyldisaccharide 4'-kinase activity	PMID:9268317^[1]	ECO:0000314			F	Fig.5	complete
	GO:0009245	lipid A biosynthetic process	PMID:9268317^[1]	ECO:0000314			P	Fig.11	complete
	GO:0009029	tetraacyldisaccharide 4'-kinase activity	PMID:9575203^[2]	ECO:0000315			F	Figure 9	complete
involved_in	GO:0009245	lipid A biosynthetic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11409 PANTHER:PTN001249227	P	Seeded From UniProt	complete
involved_in	GO:0009244	lipopolysaccharide core region biosynthetic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11409 PANTHER:PTN001249227	P	Seeded From UniProt	complete
enables	GO:0009029	tetraacyldisaccharide 4'-kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11409 PANTHER:PTN002014367 UniProtKB:Q8LEA0	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11409 PANTHER:PTN001249227	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:9268317^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009245	lipid A biosynthetic process	PMID:9268317^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0009029	tetraacyldisaccharide 4'-kinase activity	PMID:9575203^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0009029	tetraacyldisaccharide 4'-kinase activity	PMID:9268317^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:9268317^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0009245	lipid A biosynthetic process	PMID:9575203^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009244	lipopolysaccharide core region biosynthetic process	PMID:9575203^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:9268317^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003758	F	Seeded From UniProt	complete
enables	GO:0009029	tetraacyldisaccharide 4'-kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003758	F	Seeded From UniProt	complete
involved_in	GO:0009245	lipid A biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003758	P	Seeded From UniProt	complete
enables	GO:0009029	tetraacyldisaccharide 4'-kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.130	F	Seeded From UniProt	complete
involved_in	GO:0009245	lipid A biosynthetic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000085119	P	Seeded From UniProt	complete
enables	GO:0009029	tetraacyldisaccharide 4'-kinase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000085119	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000085119	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0009245	lipid A biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0441	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Garrett, TA et al. (1997) Identification of the gene encoding the Escherichia coli lipid A 4'-kinase. Facile phosphorylation of endotoxin analogs with recombinant LpxK. J. Biol. Chem. 272 21855-64 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Garrett, TA et al. (1998) Accumulation of a lipid A precursor lacking the 4'-phosphate following inactivation of the Escherichia coli lpxK gene. J. Biol. Chem. 273 12457-65 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9268317-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Garrett, TA et al. (1997) Identification of the gene encoding the Escherichia coli lipid A 4'-kinase. Facile phosphorylation of endotoxin analogs with recombinant LpxK. J. Biol. Chem. 272 21855-64 PubMed GONUTS page

[PMID:9575203-2] 2.0 ^2.1 ^2.2 ^2.3 Garrett, TA et al. (1998) Accumulation of a lipid A precursor lacking the 4'-phosphate following inactivation of the Escherichia coli lpxK gene. J. Biol. Chem. 273 12457-65 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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ECOLI:LPXK

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