ECOLI:LPOB

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	lpoB (synonyms: ycfM)
Protein Name(s)	Penicillin-binding protein activator LpoB PBP activator LpoB Lipoprotein activator of PBP from the outer membrane B
External Links
UniProt	P0AB38
EMBL	U00096 AP009048
PIR	F64854
RefSeq	NP_415623.1 YP_489373.1
ProteinModelPortal	P0AB38
SMR	P0AB38
IntAct	P0AB38
STRING	511145.b1105
PaxDb	P0AB38
PRIDE	P0AB38
EnsemblBacteria	AAC74189 BAA35912
GeneID	12934033 948536
KEGG	ecj:Y75_p1075 eco:b1105
PATRIC	32117453
EchoBASE	EB3205
EcoGene	EG13431
eggNOG	COG3417
HOGENOM	HOG000119084
KO	K07337
OMA	EIVWSGN
OrthoDB	EOG6SJJMG
BioCyc	EcoCyc:G6565-MONOMER ECOL316407:JW5157-MONOMER
PRO	PR:P0AB38
Proteomes	UP000000318 UP000000625
Genevestigator	P0AB38
GO	GO:0009279 GO:0031241 GO:0019899 GO:0030234 GO:0009252 GO:0050790 GO:0008360
HAMAP	MF_01889
InterPro	IPR014094
Pfam	PF13036
TIGRFAMs	TIGR02722
PROSITE	PS51257

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0051301	cell division	PMID:21183073^[1]	ECO:0000316		UniProtKB:P02919	P	Figure 3A and C	complete
part_of	GO:0031241	periplasmic side of cell outer membrane	PMID:21183073^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0030234	enzyme regulator activity	PMID:21183073^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0009252	peptidoglycan biosynthetic process	PMID:21183073^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031241	periplasmic side of cell outer membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13431 PANTHER:PTN002221028	C	Seeded From UniProt	complete
enables	GO:0030234	enzyme regulator activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13431 PANTHER:PTN002221028	F	Seeded From UniProt	complete
involved_in	GO:0009252	peptidoglycan biosynthetic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13431 PANTHER:PTN002221028	P	Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	PMID:24821816^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	PMID:21183073^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:27709766^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02919	F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:24821816^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02919	F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:21183074^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02919	F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:21183073^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02919	F	Seeded From UniProt	complete
part_of	GO:0009279	cell outer membrane	PMID:21183074^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009279	cell outer membrane	PMID:21183073^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009252	peptidoglycan biosynthetic process	PMID:21183074^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009252	peptidoglycan biosynthetic process	PMID:21183073^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008047	enzyme activator activity	PMID:24821816^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008047	enzyme activator activity	PMID:24821816^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008047	enzyme activator activity	PMID:21183073^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0009252	peptidoglycan biosynthetic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000058577	P	Seeded From UniProt	complete
enables	GO:0030234	enzyme regulator activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000058577	F	Seeded From UniProt	complete
part_of	GO:0031241	periplasmic side of cell outer membrane	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000058577	C	Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0133	P	Seeded From UniProt	complete
involved_in	GO:0009252	peptidoglycan biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0573	P	Seeded From UniProt	complete
part_of	GO:0009279	cell outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0998 UniProtKB-SubCell:SL-0040	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Typas, A et al. (2010) Regulation of peptidoglycan synthesis by outer-membrane proteins. Cell 143 1097-109 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Egan, AJ et al. (2014) Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B. Proc. Natl. Acad. Sci. U.S.A. 111 8197-202 PubMed GONUTS page
↑ Van't Veer, IL et al. (2016) Site-Specific Immobilization of the Peptidoglycan Synthase PBP1B on a Surface Plasmon Resonance Chip Surface. Chembiochem 17 2250-2256 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Paradis-Bleau, C et al. (2010) Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases. Cell 143 1110-20 PubMed GONUTS page

[PMID:21183073-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Typas, A et al. (2010) Regulation of peptidoglycan synthesis by outer-membrane proteins. Cell 143 1097-109 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24821816-3] 3.0 ^3.1 ^3.2 ^3.3 Egan, AJ et al. (2014) Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B. Proc. Natl. Acad. Sci. U.S.A. 111 8197-202 PubMed GONUTS page

[PMID:27709766-4] Van't Veer, IL et al. (2016) Site-Specific Immobilization of the Peptidoglycan Synthase PBP1B on a Surface Plasmon Resonance Chip Surface. Chembiochem 17 2250-2256 PubMed GONUTS page

[PMID:21183074-5] 5.0 ^5.1 ^5.2 Paradis-Bleau, C et al. (2010) Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases. Cell 143 1110-20 PubMed GONUTS page

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ECOLI:LPOB

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