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ECOLI:ISPG
Contents
| Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
| Gene Name(s) | ispG (synonyms: gcpE) | |
| Protein Name(s) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase Protein GcpE Protein E | |
| External Links | ||
| UniProt | P62620 | |
| EMBL | X64451 AY033515 U00096 AP009048 M11843 | |
| PIR | S23058 | |
| RefSeq | NP_417010.1 YP_490743.1 | |
| ProteinModelPortal | P62620 | |
| SMR | P62620 | |
| DIP | DIP-35832N | |
| IntAct | P62620 | |
| STRING | 511145.b2515 | |
| PaxDb | P62620 | |
| PRIDE | P62620 | |
| EnsemblBacteria | AAC75568 BAA16402 | |
| GeneID | 12931596 946991 | |
| KEGG | ecj:Y75_p2468 eco:b2515 | |
| PATRIC | 32120423 | |
| EchoBASE | EB0365 | |
| EcoGene | EG10370 | |
| eggNOG | COG0821 | |
| HOGENOM | HOG000261019 | |
| InParanoid | P62620 | |
| KO | K03526 | |
| OMA | HNGMKIA | |
| OrthoDB | EOG67Q96Z | |
| PhylomeDB | P62620 | |
| BioCyc | EcoCyc:EG10370-MONOMER ECOL316407:JW2499-MONOMER MetaCyc:EG10370-MONOMER | |
| UniPathway | UPA00056 | |
| PRO | PR:P62620 | |
| Proteomes | UP000000318 UP000000625 | |
| Genevestigator | P62620 | |
| GO | GO:0051539 GO:0046429 GO:0005506 GO:0046872 GO:0019288 GO:0016114 GO:0006744 | |
| Gene3D | 3.20.20.70 | |
| HAMAP | MF_00159 | |
| InterPro | IPR013785 IPR011005 IPR016425 IPR004588 | |
| Pfam | PF04551 | |
| PIRSF | PIRSF004640 | |
| SUPFAM | SSF51717 | |
| TIGRFAMs | TIGR00612 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0046429 |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity |
ECO:0000021 |
|
F |
Table 1 shows conversion of 2-C-methyl-d-eythritol 2,4-cyclodiphosphate into (E)-4-hydroxy-3-methylbut-2-enyl diphosphate by GcpE in the presence of thylakoids and light |
complete | ||||
|
enables |
GO:0046429 |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10370 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019288 |
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10370 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051539 |
4 iron, 4 sulfur cluster binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046429 |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019288 |
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019288 |
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005506 |
iron ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008299 |
isoprenoid biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016114 |
terpenoid biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044237 |
cellular metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046429 |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016114 |
terpenoid biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000001261 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051539 |
4 iron, 4 sulfur cluster binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000001261 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046429 |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000001261 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051536 |
iron-sulfur cluster binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008299 |
isoprenoid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051539 |
4 iron, 4 sulfur cluster binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019288 |
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00056 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Seemann, M et al. (2006) Isoprenoid biosynthesis in plant chloroplasts via the MEP pathway: direct thylakoid/ferredoxin-dependent photoreduction of GcpE/IspG. FEBS Lett. 580 1547-52 PubMed GONUTS page
- ↑ 2.0 2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Seemann, M et al. (2002) Isoprenoid biosynthesis through the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) is a [4Fe-4S] protein. Angew. Chem. Int. Ed. Engl. 41 4337-9 PubMed GONUTS page
- ↑ 4.0 4.1 Zepeck, F et al. (2005) Biosynthesis of isoprenoids. purification and properties of IspG protein from Escherichia coli. J. Org. Chem. 70 9168-74 PubMed GONUTS page
- ↑ Altincicek, B et al. (2001) GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. J. Bacteriol. 183 2411-6 PubMed GONUTS page
- ↑ Campos, N et al. (2001) Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli. FEBS Lett. 488 170-3 PubMed GONUTS page
- ↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
- ↑ Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page
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