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ECOLI:HIUH

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) hiuH (synonyms: yedX)
Protein Name(s) 5-hydroxyisourate hydrolase

HIU hydrolase HIUHase Transthyretin-like protein TLP Transthyretin-related protein TRP

External Links
UniProt P76341
EMBL U00096
AP009048
PIR F64961
RefSeq NP_416479.1
YP_490220.1
PDB 2G2N
2G2P
2IGL
PDBsum 2G2N
2G2P
2IGL
ProteinModelPortal P76341
SMR P76341
DIP DIP-11854N
IntAct P76341
STRING 511145.b1970
EnsemblBacteria AAC75036
BAE76558
GeneID 12931388
946485
KEGG ecj:Y75_p1937
eco:b1970
PATRIC 32119271
EchoBASE EB3799
EcoGene EG14046
eggNOG COG2351
HOGENOM HOG000251776
InParanoid P76341
KO K07127
OMA SAFHEYA
OrthoDB EOG6F55J8
PhylomeDB P76341
BioCyc EcoCyc:G7058-MONOMER
ECOL316407:JW1953-MONOMER
EvolutionaryTrace P76341
PRO PR:P76341
Proteomes UP000000318
UP000000625
Genevestigator P76341
GO GO:0042597
GO:0033971
GO:0006144
GO:0006810
Gene3D 2.60.40.180
InterPro IPR014306
IPR023418
IPR000895
IPR023416
IPR023419
Pfam PF00576
PRINTS PR00189
SMART SM00095
SUPFAM SSF49472
TIGRFAMs TIGR02962
PROSITE PS00768
PS00769

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006144

purine nucleobase metabolic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000044586
ZFIN:ZDB-GENE-060825-253

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:18656475[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:12542701[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0033971

hydroxyisourate hydrolase activity

PMID:16098976[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006144

purine nucleobase metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014306

P

Seeded From UniProt

complete

enables

GO:0033971

hydroxyisourate hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014306

F

Seeded From UniProt

complete

enables

GO:0033971

hydroxyisourate hydrolase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.2.17

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0042597

periplasmic space

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0574
UniProtKB-SubCell:SL-0200

C

Seeded From UniProt

complete

involved_in

GO:0006144

purine nucleobase metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0659

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. Santos, SD et al. (2008) Amyloidogenic properties of transthyretin-like protein (TLP) from Escherichia coli. FEBS Lett. 582 2893-8 PubMed GONUTS page
  3. Eneqvist, T et al. (2003) The transthyretin-related protein family. Eur. J. Biochem. 270 518-32 PubMed GONUTS page
  4. Lee, Y et al. (2005) Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. FEBS Lett. 579 4769-74 PubMed GONUTS page