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ECOLI:HELD

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) helD
Protein Name(s) Helicase IV

75 kDa helicase

External Links
UniProt P15038
EMBL J04726
U00096
AP009048
PIR A64837
RefSeq NP_415482.1
YP_489234.1
ProteinModelPortal P15038
SMR P15038
DIP DIP-9876N
IntAct P15038
MINT MINT-1226516
STRING 511145.b0962
BindingDB P15038
ChEMBL CHEMBL4405
PaxDb P15038
PRIDE P15038
EnsemblBacteria AAC74048
BAA35727
GeneID 12934368
946227
KEGG ecj:Y75_p0934
eco:b0962
PATRIC 32117143
EchoBASE EB0421
EcoGene EG10426
eggNOG COG0210
HOGENOM HOG000118816
InParanoid P15038
KO K03658
OMA HYFGEGD
OrthoDB EOG6HJ254
PhylomeDB P15038
BioCyc EcoCyc:EG10426-MONOMER
ECOL316407:JW0945-MONOMER
PRO PR:P15038
Proteomes UP000000318
UP000000625
Genevestigator P15038
GO GO:0033202
GO:0016020
GO:0005524
GO:0043140
GO:0003677
GO:0000155
GO:0032508
GO:0006310
Gene3D 3.40.50.300
InterPro IPR014017
IPR000212
IPR003661
IPR022161
IPR027417
IPR014016
PANTHER PTHR11070
Pfam PF12462
PF00580
PF13361
SMART SM00388
SUPFAM SSF52540
PROSITE PS51198

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0043140

ATP-dependent 3'-5' DNA helicase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10426
PANTHER:PTN000116141
SGD:S000005455
UniProtKB:A0A1D8PUB1
UniProtKB:P9WMQ1
UniProtKB:Q8I3W6

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11064
PANTHER:PTN000116141
PomBase:SPAC4H3.05
PomBase:SPBC336.01
SGD:S000003628
UniProtKB:F1ND48
UniProtKB:G3XD04
UniProtKB:P9WMQ1

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10426
EcoGene:EG11064
PANTHER:PTN000869814
UniProtKB:P9WMQ3

C

Seeded From UniProt

complete

involved_in

GO:0000725

recombinational repair

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000116141
PomBase:SPAC4H3.05
PomBase:SPBC336.01
UniProtKB:F1ND48

P

Seeded From UniProt

complete

enables

GO:0043140

ATP-dependent 3'-5' DNA helicase activity

PMID:2822720[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0033202

DNA helicase complex

PMID:2822720[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

PMID:8335623[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032508

DNA duplex unwinding

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004003

P

Seeded From UniProt

complete

involved_in

GO:0032508

DNA duplex unwinding

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0043140

P

Seeded From UniProt

complete

involved_in

GO:0032508

DNA duplex unwinding

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0043140

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000212

F

Seeded From UniProt

complete

enables

GO:0004003

ATP-dependent DNA helicase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000212

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000212
InterPro:IPR014016
InterPro:IPR014017
InterPro:IPR034739

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014017

F

Seeded From UniProt

complete

enables

GO:0004386

helicase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0347

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. 2.0 2.1 Wood, ER & Matson, SW (1987) Purification and characterization of a new DNA-dependent ATPase with helicase activity from Escherichia coli. J. Biol. Chem. 262 15269-76 PubMed GONUTS page
  3. Mendonca, VM et al. (1993) Double helicase II (uvrD)-helicase IV (helD) deletion mutants are defective in the recombination pathways of Escherichia coli. J. Bacteriol. 175 4641-51 PubMed GONUTS page
  4. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page