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ECOLI:GLNK

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) glnK (synonyms: ybaI)
Protein Name(s) Nitrogen regulatory protein P-II 2
External Links
UniProt P0AC55
EMBL U40429
S79842
U82664
U00096
AP009048
PIR B64775
RefSeq NP_414984.1
YP_488742.1
PDB 1GNK
2GNK
2NS1
2NUU
PDBsum 1GNK
2GNK
2NS1
2NUU
ProteinModelPortal P0AC55
SMR P0AC55
DIP DIP-35006N
IntAct P0AC55
MINT MINT-1309225
STRING 511145.b0450
SWISS-2DPAGE P0AC55
PaxDb P0AC55
PRIDE P0AC55
EnsemblBacteria AAC73553
BAE76230
GeneID 12934155
945087
KEGG ecj:Y75_p0438
eco:b0450
PATRIC 32116055
EchoBASE EB2108
EcoGene EG12191
eggNOG COG0347
HOGENOM HOG000017847
InParanoid P0AC55
KO K04752
OMA MVEPAIE
OrthoDB EOG69GZGV
PhylomeDB P0AC55
BioCyc EcoCyc:PROTEIN-PII2
ECOL316407:JW0440-MONOMER
MetaCyc:PROTEIN-PII2
EvolutionaryTrace P0AC55
PRO PR:P0AC55
Proteomes UP000000318
UP000000625
Genevestigator P0AC55
GO GO:0030234
GO:0042802
GO:0000166
GO:0045848
GO:0006355
GO:0006351
Gene3D 3.30.70.120
InterPro IPR002187
IPR011322
IPR015867
IPR017918
IPR002332
Pfam PF00543
PRINTS PR00340
SMART SM00938
SUPFAM SSF54913
PROSITE PS00638
PS51343
PS00496

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0042802

identical protein binding

PMID:24561554[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P0AC55

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:15150219[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P0AC55

F

Seeded From UniProt

complete

involved_in

GO:0045848

positive regulation of nitrogen utilization

PMID:12366843[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050790

regulation of catalytic activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0030234

P

Seeded From UniProt

complete

GO:0015696

ammonium transport

PMID:21134373[4]

ECO:0000315

P

Figure 2. shows how glnK binds with AmtB to physically block the exit of ammonia from the cytoplasm.

complete

involved_in

GO:0006808

regulation of nitrogen utilization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002187
InterPro:IPR002332
InterPro:IPR017918

P

Seeded From UniProt

complete

GO:0009399

nitrogen fixation

PMID:12366843[3]

ECO:0000315

P

Figure 3. indicates that glnK is required to recover from nitrogen starvation. The figure shows the regrowth of E. coli with glnK

complete

enables

GO:0030234

enzyme regulator activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002187
InterPro:IPR002332
InterPro:IPR017918

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Rajagopala, SV et al. (2014) The binary protein-protein interaction landscape of Escherichia coli. Nat. Biotechnol. 32 285-90 PubMed GONUTS page
  2. Burillo, S et al. (2004) Interactions between the nitrogen signal transduction protein PII and N-acetyl glutamate kinase in organisms that perform oxygenic photosynthesis. J. Bacteriol. 186 3346-54 PubMed GONUTS page
  3. 3.0 3.1 Blauwkamp, TA & Ninfa, AJ (2002) Physiological role of the GlnK signal transduction protein of Escherichia coli: survival of nitrogen starvation. Mol. Microbiol. 46 203-14 PubMed GONUTS page
  4. Boogerd, FC et al. (2011) AmtB-mediated NH3 transport in prokaryotes must be active and as a consequence regulation of transport by GlnK is mandatory to limit futile cycling of NH4(+)/NH3. FEBS Lett. 585 23-8 PubMed GONUTS page