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ECOLI:GLMU

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) glmU (synonyms: yieA)
Protein Name(s) Bifunctional protein GlmU

UDP-N-acetylglucosamine pyrophosphorylase N-acetylglucosamine-1-phosphate uridyltransferase Glucosamine-1-phosphate N-acetyltransferase

External Links
UniProt P0ACC7
EMBL X01631
L10328
L10328
U00096
AP009048
PIR C65176
RefSeq NP_418186.1
YP_491699.1
PDB 1FWY
1FXJ
1HV9
2OI5
2OI6
2OI7
3TWD
4AA7
PDBsum 1FWY
1FXJ
1HV9
2OI5
2OI6
2OI7
3TWD
4AA7
ProteinModelPortal P0ACC7
SMR P0ACC7
DIP DIP-31844N
IntAct P0ACC7
MINT MINT-1252604
STRING 511145.b3730
BindingDB P0ACC7
PaxDb P0ACC7
PRIDE P0ACC7
EnsemblBacteria AAC76753
BAE77558
GeneID 12933149
948246
KEGG ecj:Y75_p3438
eco:b3730
PATRIC 32122957
EchoBASE EB1184
EcoGene EG11198
eggNOG COG1207
HOGENOM HOG000283476
InParanoid P0ACC7
KO K04042
OMA FAHARPK
OrthoDB EOG6Z6FQZ
PhylomeDB P0ACC7
BioCyc EcoCyc:NAG1P-URIDYLTRANS-MONOMER
ECOL316407:JW3708-MONOMER
MetaCyc:NAG1P-URIDYLTRANS-MONOMER
SABIO-RK P0ACC7
UniPathway UPA00113
UPA00113
UPA00973
EvolutionaryTrace P0ACC7
PRO PR:P0ACC7
Proteomes UP000000318
UP000000625
Genevestigator P0ACC7
GO GO:0005737
GO:0019134
GO:0042802
GO:0000287
GO:0003977
GO:0000902
GO:0071555
GO:0009245
GO:0009103
GO:0009252
GO:0008360
GO:0006048
Gene3D 3.90.550.10
HAMAP MF_01631
InterPro IPR005882
IPR001451
IPR018357
IPR025877
IPR029044
IPR011004
Pfam PF00132
PF12804
SUPFAM SSF51161
SSF53448
TIGRFAMs TIGR01173
PROSITE PS00101

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0042802

identical protein binding

PMID:21370307[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019134

glucosamine-1-phosphate N-acetyltransferase activity

PMID:8083170[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006048

UDP-N-acetylglucosamine biosynthetic process

PMID:8407787[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15911532[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003977

UDP-N-acetylglucosamine diphosphorylase activity

PMID:8555230[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

PMID:8083170[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005882

F

Seeded From UniProt

complete

involved_in

GO:0000902

cell morphogenesis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005882

P

Seeded From UniProt

complete

enables

GO:0003977

UDP-N-acetylglucosamine diphosphorylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005882
InterPro:IPR038009

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005882

C

Seeded From UniProt

complete

involved_in

GO:0006048

UDP-N-acetylglucosamine biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038009

P

Seeded From UniProt

complete

involved_in

GO:0009103

lipopolysaccharide biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005882

P

Seeded From UniProt

complete

involved_in

GO:0009252

peptidoglycan biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005882

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018357

F

Seeded From UniProt

complete

enables

GO:0019134

glucosamine-1-phosphate N-acetyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005882
InterPro:IPR038009

F

Seeded From UniProt

complete

enables

GO:0019134

glucosamine-1-phosphate N-acetyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.1.157

F

Seeded From UniProt

complete

enables

GO:0003977

UDP-N-acetylglucosamine diphosphorylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.7.23

F

Seeded From UniProt

complete

enables

GO:0019134

glucosamine-1-phosphate N-acetyltransferase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000081051

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000081051

F

Seeded From UniProt

complete

enables

GO:0003977

UDP-N-acetylglucosamine diphosphorylase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000081051

F

Seeded From UniProt

complete

involved_in

GO:0000902

cell morphogenesis

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000081051

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000081051

C

Seeded From UniProt

complete

involved_in

GO:0009252

peptidoglycan biosynthetic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000081051

P

Seeded From UniProt

complete

enables

GO:0016746

transferase activity, transferring acyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0012

F

Seeded From UniProt

complete

enables

GO:0016779

nucleotidyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0548

F

Seeded From UniProt

complete

involved_in

GO:0009252

peptidoglycan biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0573

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

involved_in

GO:0008360

regulation of cell shape

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0133

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0071555

cell wall organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0961

P

Seeded From UniProt

complete

involved_in

GO:0006048

UDP-N-acetylglucosamine biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00113

P

Seeded From UniProt

complete

involved_in

GO:0009245

lipid A biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00973

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Trempe, JF et al. (2011) Self-association studies of the bifunctional N-acetylglucosamine-1-phosphate uridyltransferase from Escherichia coli. Protein Sci. 20 745-52 PubMed GONUTS page
  2. ↑ 2.0 2.1 Mengin-Lecreulx, D & van Heijenoort, J (1994) Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis. J. Bacteriol. 176 5788-95 PubMed GONUTS page
  3. ↑ Mengin-Lecreulx, D & van Heijenoort, J (1993) Identification of the glmU gene encoding N-acetylglucosamine-1-phosphate uridyltransferase in Escherichia coli. J. Bacteriol. 175 6150-7 PubMed GONUTS page
  4. ↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
  5. ↑ Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page
  6. ↑ Gehring, AM et al. (1996) Acetyltransfer precedes uridylyltransfer in the formation of UDP-N-acetylglucosamine in separable active sites of the bifunctional GlmU protein of Escherichia coli. Biochemistry 35 579-85 PubMed GONUTS page
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