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ECOLI:GLGB

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) glgB
Protein Name(s) 1,4-alpha-glucan branching enzyme GlgB

1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase Alpha-(1->4)-glucan branching enzyme Glycogen branching enzyme BE

External Links
UniProt P07762
EMBL M13751
U18997
U00096
AP009048
PIR A25498
RefSeq NP_417890.1
YP_492001.1
PDB 1GTY
1M7X
3O7Y
3O7Z
PDBsum 1GTY
1M7X
3O7Y
3O7Z
ProteinModelPortal P07762
SMR P07762
IntAct P07762
STRING 511145.b3432
CAZy CBM48
GH13
PaxDb P07762
PRIDE P07762
EnsemblBacteria AAC76457
BAE77860
GeneID 12933509
947940
KEGG ecj:Y75_p3745
eco:b3432
PATRIC 32122304
EchoBASE EB0373
EcoGene EG10378
eggNOG COG0296
HOGENOM HOG000283037
InParanoid P07762
KO K00700
OMA DATEVWV
OrthoDB EOG6JX7GT
PhylomeDB P07762
BioCyc EcoCyc:GLYCOGEN-BRANCH-MONOMER
ECOL316407:JW3395-MONOMER
MetaCyc:GLYCOGEN-BRANCH-MONOMER
UniPathway UPA00164
EvolutionaryTrace P07762
PRO PR:P07762
Proteomes UP000000318
UP000000625
Genevestigator P07762
GO GO:0003844
GO:0043169
GO:0004553
GO:0006974
GO:0005978
Gene3D 2.60.40.10
2.60.40.1180
3.20.20.80
HAMAP MF_00685
InterPro IPR006048
IPR006407
IPR015902
IPR013780
IPR006047
IPR004193
IPR013781
IPR017853
IPR013783
IPR014756
PANTHER PTHR10357
Pfam PF00128
PF02806
PF02922
PIRSF PIRSF000463
SUPFAM SSF51445
SSF81296
TIGRFAMs TIGR01515

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0003844

1,4-alpha-glucan branching enzyme activity

PMID:12196524[1]

ECO:0000315

F

Table 5 shows sequence point mutations, deletions or truncations that result in glycogen storage disease type IV, caused by lethal or retarded function of glycogen branching enzyme.

complete
CACAO 9980

GO:0004373

glycogen (starch) synthase activity

PMID:19244233[2]

ECO:0000266

UniProtKB:Q04446


F

Table 2 presents the partial alignment of conserved residues between Escherichia coli glycogen synthase and other bacterial glycogen syntheses and plant starch syntheses.

complete
CACAO 9985

involved_in

GO:0005978

glycogen biosynthetic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10378
PANTHER:PTN000040086
UniProtKB:P9WN45

P

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000040010
TAIR:locus:2092349

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10378
PANTHER:PTN000040086

C

Seeded From UniProt

complete

enables

GO:0003844

1,4-alpha-glucan branching enzyme activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10378
PANTHER:PTN000040010
RGD:1309968
SGD:S000000737
TAIR:locus:2044903
TAIR:locus:2144608
UniProtKB:P9WN45
UniProtKB:Q01401
UniProtKB:Q04446

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:11967071[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0005978

glycogen biosynthetic process

PMID:17543954[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003844

1,4-alpha-glucan branching enzyme activity

PMID:9636047[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006047
InterPro:IPR006048

F

Seeded From UniProt

complete

enables

GO:0003844

1,4-alpha-glucan branching enzyme activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006407
InterPro:IPR037439

F

Seeded From UniProt

complete

enables

GO:0004553

hydrolase activity, hydrolyzing O-glycosyl compounds

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004193

F

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004193
InterPro:IPR006047
InterPro:IPR006048

P

Seeded From UniProt

complete

involved_in

GO:0005978

glycogen biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006407
InterPro:IPR037439

P

Seeded From UniProt

complete

enables

GO:0043169

cation binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006048

F

Seeded From UniProt

complete

enables

GO:0003844

1,4-alpha-glucan branching enzyme activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.4.1.18

F

Seeded From UniProt

complete

enables

GO:0102752

1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.4.1.18

F

Seeded From UniProt

complete

enables

GO:0003844

1,4-alpha-glucan branching enzyme activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000098355

F

Seeded From UniProt

complete

involved_in

GO:0005978

glycogen biosynthetic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000098355

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0119

P

Seeded From UniProt

complete

involved_in

GO:0005978

glycogen biosynthetic process

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0320
UniPathway:UPA00164

P

Seeded From UniProt

complete

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0328

F

Seeded From UniProt

complete

involved_in

GO:0005977

glycogen metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0321

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Abad, MC et al. (2002) The X-ray crystallographic structure of Escherichia coli branching enzyme. J. Biol. Chem. 277 42164-70 PubMed GONUTS page
  2. Sheng, F et al. (2009) The crystal structures of the open and catalytically competent closed conformation of Escherichia coli glycogen synthase. J. Biol. Chem. 284 17796-807 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. Khil, PP & Camerini-Otero, RD (2002) Over 1000 genes are involved in the DNA damage response of Escherichia coli. Mol. Microbiol. 44 89-105 PubMed GONUTS page
  5. Eydallin, G et al. (2007) Genome-wide screening of genes affecting glycogen metabolism in Escherichia coli K-12. FEBS Lett. 581 2947-53 PubMed GONUTS page
  6. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
  7. Binderup, K & Preiss, J (1998) Glutamate-459 is important for Escherichia coli branching enzyme activity. Biochemistry 37 9033-7 PubMed GONUTS page