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ECOLI:FTSY

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) ftsY (ECO:0000255 with HAMAP-Rule:MF_00920)
Protein Name(s) Signal recognition particle receptor FtsY (ECO:0000255 with HAMAP-Rule:MF_00920)

SRP receptor (ECO:0000255 with HAMAP-Rule:MF_00920)

External Links
UniProt P10121
EMBL X04398
U00039
U00096
AP009048
PIR S03130
RefSeq NP_417921.1
YP_491970.1
PDB 1FTS
2QY9
2XXA
2YHS
3ZN8
4C7O
PDBsum 1FTS
2QY9
2XXA
2YHS
3ZN8
4C7O
ProteinModelPortal P10121
SMR P10121
DIP DIP-9709N
IntAct P10121
MINT MINT-1247716
STRING 511145.b3464
TCDB 3.A.5.1.1
PaxDb P10121
PRIDE P10121
EnsemblBacteria AAC76489
BAE77829
GeneID 12933505
947978
KEGG ecj:Y75_p3714
eco:b3464
PATRIC 32122372
EchoBASE EB0342
EcoGene EG10346
eggNOG COG0552
HOGENOM HOG000036278
InParanoid P10121
KO K03110
OMA PKTHTEA
OrthoDB EOG62K1ZH
PhylomeDB P10121
BioCyc EcoCyc:EG10346-MONOMER
ECOL316407:JW3429-MONOMER
EvolutionaryTrace P10121
PRO PR:P10121
Proteomes UP000000318
UP000000625
Genevestigator P10121
GO GO:0005829
GO:0031226
GO:0005525
GO:0003924
GO:0006614
Gene3D 3.40.50.300
HAMAP MF_00920
InterPro IPR003593
IPR027417
IPR013822
IPR004390
IPR000897
Pfam PF00448
PF02881
SMART SM00382
SM00962
SM00963
SUPFAM SSF47364
SSF52540
TIGRFAMs TIGR00064
PROSITE PS00300

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005886

plasma membrane

PMID:21255212[1]

ECO:0000314

C

FIg 1: fluorescence microscopy shows localization of FTSY to plasma membrane

complete

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

PMID:8999901[2]

ECO:0000315

P

figure 1: effect of FtsY depletion

complete

GO:0005525

GTP binding

PMID:7660124[3]

ECO:0000315

F

figure 1

complete

part_of

GO:0016020

membrane

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000169915
UniProtKB:P08240

C

Seeded From UniProt

complete

involved_in

GO:0006605

protein targeting

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10346
PANTHER:PTN000169915
SGD:S000002700
TAIR:locus:2050777

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10346
PANTHER:PTN001695963
UniProtKB:P9WGD9

C

Seeded From UniProt

complete

enables

GO:0005047

signal recognition particle binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000169915
SGD:S000002700

F

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10346
PANTHER:PTN000169915

F

Seeded From UniProt

complete

part_of

GO:0031226

intrinsic component of plasma membrane

PMID:8107852[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031226

intrinsic component of plasma membrane

PMID:19414018[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0019897

extrinsic component of plasma membrane

PMID:8194520[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

PMID:8107852[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:19912622[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:8194520[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

PMID:8107852[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:8107852[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000897
InterPro:IPR013822

F

Seeded From UniProt

complete

involved_in

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000897
InterPro:IPR004390
InterPro:IPR013822

P

Seeded From UniProt

complete

involved_in

GO:0006612

protein targeting to membrane

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000100357

P

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000100357

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000100357

F

Seeded From UniProt

complete

part_of

GO:0031226

intrinsic component of plasma membrane

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000100357

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000100357

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-KW:KW-0997
UniProtKB-SubCell:SL-0037

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Kuhn, P et al. (2011) The bacterial SRP receptor, SecA and the ribosome use overlapping binding sites on the SecY translocon. Traffic 12 563-78 PubMed GONUTS page
  2. ↑ Seluanov, A & Bibi, E (1997) FtsY, the prokaryotic signal recognition particle receptor homologue, is essential for biogenesis of membrane proteins. J. Biol. Chem. 272 2053-5 PubMed GONUTS page
  3. ↑ Powers, T & Walter, P (1995) Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases. Science 269 1422-4 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Miller, JD et al. (1994) Interaction of E. coli Ffh/4.5S ribonucleoprotein and FtsY mimics that of mammalian signal recognition particle and its receptor. Nature 367 657-9 PubMed GONUTS page
  6. ↑ Braig, D et al. (2009) Two cooperating helices constitute the lipid-binding domain of the bacterial SRP receptor. J. Mol. Biol. 390 401-13 PubMed GONUTS page
  7. ↑ 7.0 7.1 Luirink, J et al. (1994) An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY. EMBO J. 13 2289-96 PubMed GONUTS page
  8. ↑ Mircheva, M et al. (2009) Predominant membrane localization is an essential feature of the bacterial signal recognition particle receptor. BMC Biol. 7 76 PubMed GONUTS page
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