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ECOLI:FOLX

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) folX
Protein Name(s) D-erythro-7,8-dihydroneopterin triphosphate epimerase

Dihydroneopterin triphosphate 2'-epimerase

External Links
UniProt P0AC19
EMBL X96709
U47639
AP009048
U00096
PIR E65002
RefSeq NP_416806.1
YP_490545.1
PDB 1B9L
PDBsum 1B9L
ProteinModelPortal P0AC19
SMR P0AC19
DIP DIP-9679N
IntAct P0AC19
STRING 511145.b2303
PaxDb P0AC19
PRIDE P0AC19
EnsemblBacteria AAC75363
BAA16140
GeneID 12931524
946781
KEGG ecj:Y75_p2269
eco:b2303
PATRIC 32119977
EchoBASE EB4011
EcoGene EG14263
eggNOG COG1539
HOGENOM HOG000217626
InParanoid P0AC19
KO K07589
OMA TKAIIAH
OrthoDB EOG6ND0KG
PhylomeDB P0AC19
BioCyc EcoCyc:H2NTPEPIM-MONOMER
ECOL316407:JW2300-MONOMER
MetaCyc:H2NTPEPIM-MONOMER
EvolutionaryTrace P0AC19
PRO PR:P0AC19
Proteomes UP000000318
UP000000625
Genevestigator P0AC19
GO GO:0004150
GO:0008719
GO:0006760
InterPro IPR006157
Pfam PF02152
SMART SM00905
TIGRFAMs TIGR00526

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0008719

dihydroneopterin triphosphate 2'-epimerase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG14263
PANTHER:PTN000468644

F

Seeded From UniProt

complete

involved_in

GO:0006760

folic acid-containing compound metabolic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG14263
PANTHER:PTN000468621

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG14263
PANTHER:PTN000468644

C

Seeded From UniProt

complete

enables

GO:0008719

dihydroneopterin triphosphate 2'-epimerase activity

PMID:9651328[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006760

folic acid-containing compound metabolic process

PMID:19897652[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004150

dihydroneopterin aldolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006157

F

Seeded From UniProt

complete

involved_in

GO:0006760

folic acid-containing compound metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006157

P

Seeded From UniProt

complete

enables

GO:0008719

dihydroneopterin triphosphate 2'-epimerase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:5.1.99.7

F

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0413

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. Haussmann, C et al. (1998) Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase. J. Biol. Chem. 273 17418-24 PubMed GONUTS page
  3. Pribat, A et al. (2010) FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa. J. Bacteriol. 192 475-82 PubMed GONUTS page
  4. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page