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ECOLI:FKBA
Contents
| Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
| Gene Name(s) | fkpA (synonyms: yzzS) | |
| Protein Name(s) | FKBP-type peptidyl-prolyl cis-trans isomerase FkpA
PPIase Rotamase | |
| External Links | ||
| UniProt | P45523 | |
| EMBL | L28082 U18997 U00096 AP009048 | |
| PIR | I65035 | |
| RefSeq | NP_417806.1 WP_000838250.1 | |
| PDB | 1Q6H 1Q6I 1Q6U | |
| PDBsum | 1Q6H 1Q6I 1Q6U | |
| ProteinModelPortal | P45523 | |
| SMR | P45523 | |
| DIP | DIP-9625N | |
| IntAct | P45523 | |
| MINT | MINT-1228098 | |
| STRING | 511145.b3347 | |
| SWISS-2DPAGE | P45523 | |
| PaxDb | P45523 | |
| PRIDE | P45523 | |
| EnsemblBacteria | AAC76372 BAE77944 | |
| GeneID | 947850 | |
| KEGG | eco:b3347 | |
| PATRIC | 32122126 | |
| EchoBASE | EB2737 | |
| EcoGene | EG12900 | |
| eggNOG | COG0545 | |
| HOGENOM | HOG000154888 | |
| InParanoid | P45523 | |
| KO | K03772 | |
| OMA | QAPKNAA | |
| OrthoDB | EOG6DRPKW | |
| PhylomeDB | P45523 | |
| BioCyc | EcoCyc:G7716-MONOMER ECOL316407:JW3309-MONOMER | |
| BRENDA | 5.2.1.8 | |
| EvolutionaryTrace | P45523 | |
| PRO | PR:P45523 | |
| Proteomes | UP000000318 UP000000625 | |
| GO | GO:0005737 GO:0030288 GO:0005528 GO:0003755 GO:0061077 GO:0000413 GO:0042026 | |
| Gene3D | 1.10.287.460 | |
| InterPro | IPR023566 IPR001179 IPR000774 | |
| PANTHER | PTHR10516 | |
| Pfam | PF00254 PF01346 | |
| PROSITE | PS50059 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0042026 |
protein refolding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030288 |
outer membrane-bounded periplasmic space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030288 |
outer membrane-bounded periplasmic space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000413 |
protein peptidyl-prolyl isomerization |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003755 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000413 |
protein peptidyl-prolyl isomerization |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003755 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006457 |
protein folding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
ECO:0000314 |
F |
Figure 2: Fluorescence traces of refolding of RNase T1 (0.2 μM) at 10 °C starting from equilibrium-denatured protein (trace a) in the absence or presence of 0.5 nM (trace b), 2 nM (trace c), and 5 nM (trace d) FkpA (calculated for the dimer). The intensity at 323 nm was followed. Inset, the refolding curves were evaluated with a double exponential fit; and the rates of the faster refolding phase, divided by the uncatalyzed rate, are plotted against the respective FkpA concentration present during the measurement. arb., arbitrary. |
complete | |||||
|
enables |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016853 |
isomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042597 |
periplasmic space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Hullmann, J et al. (2008) Periplasmic chaperone FkpA is essential for imported colicin M toxicity. Mol. Microbiol. 69 926-37 PubMed GONUTS page
- ↑ Han, MJ et al. (2014) Comparison of the large-scale periplasmic proteomes of the Escherichia coli K-12 and B strains. J. Biosci. Bioeng. 117 437-42 PubMed GONUTS page
- ↑ Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page
- ↑ Ramm, K & Plückthun, A (2000) The periplasmic Escherichia coli peptidylprolyl cis,trans-isomerase FkpA. II. Isomerase-independent chaperone activity in vitro. J. Biol. Chem. 275 17106-13 PubMed GONUTS page
b
