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ECOLI:FIS

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) fis (ECO:0000255 with HAMAP-Rule:MF_00166)
Protein Name(s) DNA-binding protein Fis (ECO:0000255 with HAMAP-Rule:MF_00166)

Factor-for-inversion stimulation protein Hin recombinational enhancer-binding protein

External Links
UniProt P0A6R3
EMBL J03245
J03816
M95784
U18997
U00096
AP009048
PIR A32142
RefSeq NP_417727.1
YP_491443.1
PDB 1ETK
1ETO
1ETQ
1ETV
1ETW
1ETX
1ETY
1F36
1FIA
1FIP
3FIS
3IV5
3JR9
3JRA
3JRB
3JRC
3JRD
3JRE
3JRF
3JRG
3JRH
3JRI
4FIS
PDBsum 1ETK
1ETO
1ETQ
1ETV
1ETW
1ETX
1ETY
1F36
1FIA
1FIP
3FIS
3IV5
3JR9
3JRA
3JRB
3JRC
3JRD
3JRE
3JRF
3JRG
3JRH
3JRI
4FIS
DisProt DP00422
ProteinModelPortal P0A6R3
SMR P0A6R3
DIP DIP-47975N
IntAct P0A6R3
MINT MINT-1225073
STRING 511145.b3261
PaxDb P0A6R3
PRIDE P0A6R3
EnsemblBacteria AAC76293
BAE77302
GeneID 12932870
947697
KEGG ecj:Y75_p3179
eco:b3261
PATRIC 32121952
EchoBASE EB0313
EcoGene EG10317
eggNOG COG2901
HOGENOM HOG000256331
InParanoid P0A6R3
KO K03557
OMA MSDNANL
OrthoDB EOG67HJXZ
PhylomeDB P0A6R3
BioCyc EcoCyc:PD00196
ECOL316407:JW3229-MONOMER
EvolutionaryTrace P0A6R3
PRO PR:P0A6R3
Proteomes UP000000318
UP000000625
Genevestigator P0A6R3
GO GO:0000787
GO:0003677
GO:0043565
GO:0003700
GO:0034401
GO:0006355
GO:0006351
Gene3D 1.10.10.60
HAMAP MF_00166
InterPro IPR005412
IPR009057
IPR002197
Pfam PF02954
PIRSF PIRSF002097
PRINTS PR01591
PR01590
SUPFAM SSF46689

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0003677

DNA binding

PMID:21097887[1]

ECO:0000314

F

Figure 4 demonstrates temporal patterns of Fis binding to the bacterial chromosome.

complete

involved_in

GO:0045911

positive regulation of DNA recombination

PMID:9362499[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000985

bacterial-type RNA polymerase core promoter sequence-specific DNA binding

PMID:9362499[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031421

invertasome

PMID:9362499[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:1946369[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:1619650[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:9362499[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032359

provirus excision

PMID:9362499[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0044374

sequence-specific DNA binding, bending

PMID:9362499[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001121

bacterial transcription

PMID:9362499[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001216

DNA-binding transcription activator activity

PMID:9362499[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:11183780[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:21778209[6]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_019062.1

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:21778209[6]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001217

DNA-binding transcription repressor activity

PMID:21778209[6]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_019062.1

F

Seeded From UniProt

complete

enables

GO:0001217

DNA-binding transcription repressor activity

PMID:21778209[6]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:21778209[6]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_019062.1

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:21778209[6]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10317
PANTHER:PTN002936601

F

Seeded From UniProt

complete

involved_in

GO:0034401

chromatin organization involved in regulation of transcription

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10317
PANTHER:PTN002936601

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10317
PANTHER:PTN002936601

P

Seeded From UniProt

complete

part_of

GO:0000787

cytoplasmic nucleosome

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10317
PANTHER:PTN002936601

C

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:10551881[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0034401

chromatin organization involved in regulation of transcription

PMID:11812843[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009314

response to radiation

PMID:27718375[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:17233826[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15911532[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:18340041[14]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000787

cytoplasmic nucleosome

PMID:10320479[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001217

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001217

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001216

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005412
InterPro:IPR009057

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005412

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002197

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000079176

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000079176

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0009295

nucleoid

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0187

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Kahramanoglou, C et al. (2011) Direct and indirect effects of H-NS and Fis on global gene expression control in Escherichia coli. Nucleic Acids Res. 39 2073-91 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Safo, MK et al. (1997) The transactivation region of the fis protein that controls site-specific DNA inversion contains extended mobile beta-hairpin arms. EMBO J. 16 6860-73 PubMed GONUTS page
  3. Yuan, HS et al. (1991) The molecular structure of wild-type and a mutant Fis protein: relationship between mutational changes and recombinational enhancer function or DNA binding. Proc. Natl. Acad. Sci. U.S.A. 88 9558-62 PubMed GONUTS page
  4. Kostrewa, D et al. (1992) Crystal structure of the factor for inversion stimulation FIS at 2.0 A resolution. J. Mol. Biol. 226 209-26 PubMed GONUTS page
  5. Cheng, YS et al. (2000) Structural analysis of the transcriptional activation region on Fis: crystal structures of six Fis mutants with different activation properties. J. Mol. Biol. 302 1139-51 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Cagle, CA et al. (2011) Regulation of the integrase and cassette promoters of the class 1 integron by nucleoid-associated proteins. Microbiology (Reading, Engl.) 157 2841-53 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. Azam, TA & Ishihama, A (1999) Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J. Biol. Chem. 274 33105-13 PubMed GONUTS page
  9. Schneider, R et al. (2001) An architectural role of the Escherichia coli chromatin protein FIS in organising DNA. Nucleic Acids Res. 29 5107-14 PubMed GONUTS page
  10. Sargentini, NJ et al. () Screen for genes involved in radiation survival of Escherichia coli and construction of a reference database. Mutat. Res. 793-794 1-14 PubMed GONUTS page
  11. Weinstein-Fischer, D & Altuvia, S (2007) Differential regulation of Escherichia coli topoisomerase I by Fis. Mol. Microbiol. 63 1131-44 PubMed GONUTS page
  12. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
  13. Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page
  14. Cho, BK et al. (2008) Genome-wide analysis of Fis binding in Escherichia coli indicates a causative role for A-/AT-tracts. Genome Res. 18 900-10 PubMed GONUTS page
  15. Ishihama, A (1999) Modulation of the nucleoid, the transcription apparatus, and the translation machinery in bacteria for stationary phase survival. Genes Cells 4 135-43 PubMed GONUTS page