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ECOLI:FADL

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) fadL (synonyms: ttr)
Protein Name(s) Long-chain fatty acid transport protein

Outer membrane FadL protein Outer membrane flp protein

External Links
UniProt P10384
EMBL M60607
U00096
AP009048
Y00552
PIR F65007
RefSeq NP_416846.2
YP_490586.1
PDB 1T16
1T1L
2R4L
2R4N
2R4O
2R4P
2R88
2R89
2R8A
3DWN
3PF1
3PGR
3PGS
3PGU
PDBsum 1T16
1T1L
2R4L
2R4N
2R4O
2R4P
2R88
2R89
2R8A
3DWN
3PF1
3PGR
3PGS
3PGU
ProteinModelPortal P10384
SMR P10384
STRING 511145.b2344
TCDB 1.B.9.1.1
PaxDb P10384
PRIDE P10384
EnsemblBacteria AAC75404
BAA16205
GeneID 12931542
946820
KEGG ecj:Y75_p2310
eco:b2344
PATRIC 32120061
EchoBASE EB0276
EcoGene EG10280
eggNOG COG2067
HOGENOM HOG000277333
InParanoid P10384
KO K06076
OMA MHGQKVT
OrthoDB EOG6Z0Q6D
PhylomeDB P10384
BioCyc EcoCyc:EG10280-MONOMER
ECOL316407:JW2341-MONOMER
MetaCyc:EG10280-MONOMER
EvolutionaryTrace P10384
PRO PR:P10384
Proteomes UP000000318
UP000000625
Genevestigator P10384
GO GO:0009279
GO:0016021
GO:0015909
InterPro IPR005017
Pfam PF03349

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009279

cell outer membrane

PMID:10806384[1]

ECO:0000314

C

Table 1

complete

part_of

GO:0031230

intrinsic component of cell outer membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002170812
UniProtKB:Q8ZNA5

C

Seeded From UniProt

complete

enables

GO:0015483

long-chain fatty acid transporting porin activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10280
PANTHER:PTN002170812

F

Seeded From UniProt

complete

enables

GO:0022834

ligand-gated channel activity

PMID:24970895[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0006869

lipid transport

PMID:19182779[4]

ECO:0000314

P

Figure 2

complete
CACAO 4808

enables

GO:0015483

long-chain fatty acid transporting porin activity

PMID:15178802[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0009279

cell outer membrane

PMID:3286621[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009279

cell outer membrane

PMID:3027089[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0015908

fatty acid transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015483

P

Seeded From UniProt

complete

involved_in

GO:0015908

fatty acid transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015483

P

Seeded From UniProt

complete

involved_in

GO:0015909

long-chain fatty acid transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015483

P

Seeded From UniProt

complete

involved_in

GO:0015909

long-chain fatty acid transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015483

P

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0022834

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0009279

cell outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0998
UniProtKB-SubCell:SL-0040

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0006869

lipid transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0445

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Molloy, MP et al. (2000) Proteomic analysis of the Escherichia coli outer membrane. Eur. J. Biochem. 267 2871-81 PubMed GONUTS page
  2. 2.0 2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. Weaver, J & Rye, HS (2014) The C-terminal tails of the bacterial chaperonin GroEL stimulate protein folding by directly altering the conformation of a substrate protein. J. Biol. Chem. 289 23219-32 PubMed GONUTS page
  4. Hearn, EM et al. (2009) Transmembrane passage of hydrophobic compounds through a protein channel wall. Nature 458 367-70 PubMed GONUTS page
  5. van den Berg, B et al. (2004) Crystal structure of the long-chain fatty acid transporter FadL. Science 304 1506-9 PubMed GONUTS page
  6. Black, PN (1988) The fadL gene product of Escherichia coli is an outer membrane protein required for uptake of long-chain fatty acids and involved in sensitivity to bacteriophage T2. J. Bacteriol. 170 2850-4 PubMed GONUTS page
  7. Black, PN et al. (1987) Purification and characterization of an outer membrane-bound protein involved in long-chain fatty acid transport in Escherichia coli. J. Biol. Chem. 262 1412-9 PubMed GONUTS page