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ECOLI:DOSC

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) dosC (synonyms: yddV)
Protein Name(s) Diguanylate cyclase DosC

DGC Direct oxygen-sensing cyclase

External Links
UniProt P0AA89
EMBL U00096
AP009048
PIR E64902
RefSeq NP_416007.3
YP_489755.1
ProteinModelPortal P0AA89
SMR P0AA89
STRING 511145.b1490
PRIDE P0AA89
DNASU 945835
EnsemblBacteria AAC74563
BAA15155
GeneID 12933168
945835
KEGG ecj:Y75_p1466
eco:b1490
PATRIC 32118274
EchoBASE EB3554
EcoGene EG13793
eggNOG COG2199
HOGENOM HOG000006777
InParanoid P0AA89
KO K13069
OMA DGHPDYE
OrthoDB EOG6G4VQG
BioCyc EcoCyc:G6784-MONOMER
ECOL316407:JW5241-MONOMER
MetaCyc:G6784-MONOMER
UniPathway UPA00599
PRO PR:P0AA89
Proteomes UP000000318
UP000000625
Genevestigator P0AA89
GO GO:0052621
GO:0005525
GO:0020037
GO:0005506
GO:0019825
GO:0015671
GO:0006355
GO:0006351
Gene3D 1.10.490.10
InterPro IPR000160
IPR009050
IPR012292
IPR029787
Pfam PF00990
SMART SM00267
SUPFAM SSF46458
SSF55073
TIGRFAMs TIGR00254
PROSITE PS50887

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0052621

diguanylate cyclase activity

PMID:19764732[1]

ECO:0000314

F

Table 2

complete
CACAO 4350

GO:0042710

biofilm formation

PMID:25012525[2]

ECO:0000314

P

Figure 1: Characterization of Biofilm Formation

complete
CACAO 10650

involved_in

GO:1902201

negative regulation of bacterial-type flagellum-dependent cell motility

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12880
EcoGene:EG13495
EcoGene:EG13496
EcoGene:EG14040
PANTHER:PTN002895351

P

Seeded From UniProt

complete

enables

GO:0052621

diguanylate cyclase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11257
EcoGene:EG11643
EcoGene:EG12880
EcoGene:EG13355
EcoGene:EG13793
EcoGene:EG14040
PANTHER:PTN002895344
UniProtKB:Q9HT84
UniProtKB:Q9HUW7
UniProtKB:Q9HW69
UniProtKB:Q9HZX6
UniProtKB:Q9I4M8

F

Seeded From UniProt

complete

involved_in

GO:0043709

cell adhesion involved in single-species biofilm formation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11643
PANTHER:PTN002895351

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12880
EcoGene:EG13477
EcoGene:EG13495
EcoGene:EG13496
EcoGene:EG13814
EcoGene:EG14040
PANTHER:PTN002895351

C

Seeded From UniProt

complete

enables

GO:0070025

carbon monoxide binding

PMID:26063650[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0052621

diguanylate cyclase activity

PMID:21067162[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0052621

diguanylate cyclase activity

PMID:16418169[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0020037

heme binding

PMID:19764732[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019825

oxygen binding

PMID:19764732[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019825

oxygen binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012292

F

Seeded From UniProt

complete

enables

GO:0020037

heme binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012292

F

Seeded From UniProt

complete

enables

GO:0052621

diguanylate cyclase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.7.65

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Tuckerman, JR et al. (2009) An oxygen-sensing diguanylate cyclase and phosphodiesterase couple for c-di-GMP control. Biochemistry 48 9764-74 PubMed GONUTS page
  2. Nascimento, HH et al. (2014) Phenotypic and genotypic characteristics associated with biofilm formation in clinical isolates of atypical enteropathogenic Escherichia coli (aEPEC) strains. BMC Microbiol. 14 184 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. Pavlou, A et al. (2015) Probing the ligand recognition and discrimination environment of the globin-coupled oxygen sensor protein YddV by FTIR and time-resolved step-scan FTIR spectroscopy. Phys Chem Chem Phys 17 17007-15 PubMed GONUTS page
  5. Kitanishi, K et al. (2010) Important roles of Tyr43 at the putative heme distal side in the oxygen recognition and stability of the Fe(II)-O2 complex of YddV, a globin-coupled heme-based oxygen sensor diguanylate cyclase. Biochemistry 49 10381-93 PubMed GONUTS page
  6. Méndez-Ortiz, MM et al. (2006) Genome-wide transcriptional profile of Escherichia coli in response to high levels of the second messenger 3',5'-cyclic diguanylic acid. J. Biol. Chem. 281 8090-9 PubMed GONUTS page