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ECOLI:DNAA

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) dnaA
Protein Name(s) Chromosomal replication initiator protein DnaA
External Links
UniProt P03004
EMBL J01602
X01861
L10328
U00096
AP009048
PIR G65172
RefSeq NP_418157.1
YP_491733.1
PDB 1J1V
2E0G
PDBsum 1J1V
2E0G
ProteinModelPortal P03004
SMR P03004
DIP DIP-9455N
IntAct P03004
MINT MINT-207293
STRING 511145.b3702
PaxDb P03004
PRIDE P03004
EnsemblBacteria AAC76725
BAE77592
GeneID 12932545
948217
KEGG ecj:Y75_p3471
eco:b3702
PATRIC 32122901
EchoBASE EB0231
EcoGene EG10235
eggNOG COG0593
HOGENOM HOG000235659
InParanoid P03004
KO K02313
OMA SWFARMD
OrthoDB EOG689HR1
PhylomeDB P03004
BioCyc EcoCyc:PD03831
ECOL316407:JW3679-MONOMER
EvolutionaryTrace P03004
PRO PR:P03004
Proteomes UP000000318
UP000000625
Genevestigator P03004
GO GO:0005737
GO:0005886
GO:0005524
GO:0003677
GO:0003688
GO:0043565
GO:0006260
GO:0006270
GO:0008156
GO:0006275
GO:0006355
GO:0006351
Gene3D 1.10.1750.10
3.40.50.300
HAMAP MF_00377
InterPro IPR003593
IPR001957
IPR020591
IPR018312
IPR013159
IPR013317
IPR024633
IPR027417
IPR010921
Pfam PF00308
PF08299
PF11638
PRINTS PR00051
SMART SM00382
SM00760
SUPFAM SSF48295
SSF52540
TIGRFAMs TIGR00362
PROSITE PS01008

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006270

DNA replication initiation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000769352
UniProtKB:P05648

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10235
PANTHER:PTN001574578

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10235
PANTHER:PTN000769352
UniProtKB:P9WNW3

C

Seeded From UniProt

complete

enables

GO:0003688

DNA replication origin binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10235
PANTHER:PTN000769352
UniProtKB:P9WNW3

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:19833870[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P03004

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:18284581[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P03004

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:10551881[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006275

regulation of DNA replication

PMID:12068813[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

PMID:12068813[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:10762265[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003688

DNA replication origin binding

PMID:19833870[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:7615570[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001957
InterPro:IPR018312

F

Seeded From UniProt

complete

enables

GO:0003688

DNA replication origin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001957
InterPro:IPR018312

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001957
InterPro:IPR013159
InterPro:IPR018312

F

Seeded From UniProt

complete

involved_in

GO:0006270

DNA replication initiation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001957
InterPro:IPR013159
InterPro:IPR018312

P

Seeded From UniProt

complete

involved_in

GO:0006275

regulation of DNA replication

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001957
InterPro:IPR013159
InterPro:IPR018312

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010921
InterPro:IPR013159

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000084164

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000084164

F

Seeded From UniProt

complete

involved_in

GO:0006270

DNA replication initiation

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000084164

P

Seeded From UniProt

complete

involved_in

GO:0006275

regulation of DNA replication

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000084164

P

Seeded From UniProt

complete

enables

GO:0003688

DNA replication origin binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000084164

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0008156

negative regulation of DNA replication

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0236

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0235

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. 2.0 2.1 Miller, DT et al. (2009) Bacterial origin recognition complexes direct assembly of higher-order DnaA oligomeric structures. Proc. Natl. Acad. Sci. U.S.A. 106 18479-84 PubMed GONUTS page
  3. Chodavarapu, S et al. (2008) Escherichia coli Dps interacts with DnaA protein to impede initiation: a model of adaptive mutation. Mol. Microbiol. 67 1331-46 PubMed GONUTS page
  4. Azam, TA & Ishihama, A (1999) Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J. Biol. Chem. 274 33105-13 PubMed GONUTS page
  5. 5.0 5.1 Ogawa, T et al. (2002) The datA locus predominantly contributes to the initiator titration mechanism in the control of replication initiation in Escherichia coli. Mol. Microbiol. 44 1367-75 PubMed GONUTS page
  6. Newman, G & Crooke, E (2000) DnaA, the initiator of Escherichia coli chromosomal replication, is located at the cell membrane. J. Bacteriol. 182 2604-10 PubMed GONUTS page
  7. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
  8. Schaper, S & Messer, W (1995) Interaction of the initiator protein DnaA of Escherichia coli with its DNA target. J. Biol. Chem. 270 17622-6 PubMed GONUTS page