ECOLI:DCUP

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	hemE (ECO:0000255 with HAMAP-Rule:MF_00218)
Protein Name(s)	Uroporphyrinogen decarboxylase (ECO:0000255 with HAMAP-Rule:MF_00218) UPD (ECO:0000255 with HAMAP-Rule:MF_00218) URO-D (ECO:0000255 with HAMAP-Rule:MF_00218)
External Links
UniProt	P29680
EMBL	D12624 U00006 U00096 AP009048
PIR	H65206
RefSeq	NP_418425.1 YP_491463.1
ProteinModelPortal	P29680
SMR	P29680
IntAct	P29680
STRING	511145.b3997
PaxDb	P29680
PRIDE	P29680
EnsemblBacteria	AAC76971 BAE77322
GeneID	12934224 948497
KEGG	ecj:Y75_p3199 eco:b3997
PATRIC	32123517
EchoBASE	EB1505
EcoGene	EG11543
eggNOG	COG0407
HOGENOM	HOG000253896
InParanoid	P29680
KO	K01599
OMA	FIDACFR
OrthoDB	EOG6VXF6H
PhylomeDB	P29680
BioCyc	EcoCyc:UROGENDECARBOX-MONOMER ECOL316407:JW3961-MONOMER MetaCyc:UROGENDECARBOX-MONOMER
UniPathway	UPA00251
PRO	PR:P29680
Proteomes	UP000000318 UP000000625
Genevestigator	P29680
GO	GO:0005737 GO:0004853 GO:0006783 GO:0006779 GO:0019353 GO:0006780
HAMAP	MF_00218
InterPro	IPR006361 IPR000257
Pfam	PF01208
TIGRFAMs	TIGR01464
PROSITE	PS00906 PS00907

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0019353	protoporphyrinogen IX biosynthetic process from glutamate	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11543 PANTHER:PTN001843918	P	Seeded From UniProt	complete
involved_in	GO:0006783	heme biosynthetic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11543 MGI:MGI:98916 PANTHER:PTN000472929 SGD:S000002454	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11543 MGI:MGI:98916 PANTHER:PTN000472929 RGD:3946 UniProtKB:P06132 UniProtKB:P9WFE1	C	Seeded From UniProt	complete
enables	GO:0004853	uroporphyrinogen decarboxylase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11543 MGI:MGI:98916 PANTHER:PTN000472929 RGD:3946 SGD:S000002454 UniProtKB:P06132	F	Seeded From UniProt	complete
involved_in	GO:0006783	heme biosynthetic process	PMID:1104578^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006780	uroporphyrinogen III biosynthetic process	PMID:1104578^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006779	porphyrin-containing compound biosynthetic process	PMID:1104578^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004853	uroporphyrinogen decarboxylase activity	PMID:1104578^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0019353	protoporphyrinogen IX biosynthetic process from glutamate	PMID:1104578^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18304323^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:15911532^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004853	uroporphyrinogen decarboxylase activity	PMID:7849561^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004853	uroporphyrinogen decarboxylase activity	PMID:1104578^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004853	uroporphyrinogen decarboxylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000257 InterPro:IPR006361	F	Seeded From UniProt	complete
involved_in	GO:0006779	porphyrin-containing compound biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000257 InterPro:IPR006361	P	Seeded From UniProt	complete
enables	GO:0004853	uroporphyrinogen decarboxylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.1.1.37	F	Seeded From UniProt	complete
enables	GO:0004853	uroporphyrinogen decarboxylase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000081074	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000081074	C	Seeded From UniProt	complete
involved_in	GO:0006779	porphyrin-containing compound biosynthetic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000081074	P	Seeded From UniProt	complete
enables	GO:0016831	carboxy-lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0210	F	Seeded From UniProt	complete
involved_in	GO:0006779	porphyrin-containing compound biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0627	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0016829	lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0456	F	Seeded From UniProt	complete
involved_in	GO:0006782	protoporphyrinogen IX biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00251	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Săsărman, A et al. (1975) Uroporphyrin-accumulating mutant of Escherichia coli K-12. J. Bacteriol. 124 1205-12 PubMed GONUTS page
↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
↑ Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page
↑ Pido, S et al. (1994) Characterization of a hemA/hemE mutant of E. coli and regulation of hemE. Cell. Mol. Biol. (Noisy-le-grand) 40 945-56 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1104578-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Săsărman, A et al. (1975) Uroporphyrin-accumulating mutant of Escherichia coli K-12. J. Bacteriol. 124 1205-12 PubMed GONUTS page

[PMID:18304323-3] Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page

[PMID:15911532-4] Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page

[PMID:7849561-5] Pido, S et al. (1994) Characterization of a hemA/hemE mutant of E. coli and regulation of hemE. Cell. Mol. Biol. (Noisy-le-grand) 40 945-56 PubMed GONUTS page

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ECOLI:DCUP

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