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ECOLI:CSGD

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) csgD
Protein Name(s) CsgBAC operon transcriptional regulatory protein
External Links
UniProt P52106
EMBL X90754
U00096
AP009048
AF081826
PIR S70786
RefSeq NP_415558.1
YP_489307.1
ProteinModelPortal P52106
SMR P52106
DIP DIP-9328N
IntAct P52106
MINT MINT-1293972
STRING 511145.b1040
PaxDb P52106
PRIDE P52106
EnsemblBacteria AAC74124
BAA35830
GeneID 12931070
949119
KEGG ecj:Y75_p1009
eco:b1040
PATRIC 32117313
EchoBASE EB3186
EcoGene EG13410
eggNOG COG2771
HOGENOM HOG000284130
KO K04333
OMA RKNNNIR
OrthoDB EOG69GZGV
PhylomeDB P52106
BioCyc EcoCyc:PD01379
ECOL316407:JW1023-MONOMER
PRO PR:P52106
Proteomes UP000000318
UP000000625
Genevestigator P52106
GO GO:0005886
GO:0000986
GO:0003700
GO:2000144
GO:1900190
GO:0006351
Gene3D 1.10.10.10
InterPro IPR016032
IPR000792
IPR011991
Pfam PF00196
PRINTS PR00038
SMART SM00421
SUPFAM SSF46894
PROSITE PS00622
PS50043

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0042710

biofilm formation

PMID:17873038[1]

ECO:0000315

P

Figure 1: curli fiber production due to increased penicillin production after plasmid with CsgD gene introduced.

complete
CACAO 4043

part_of

GO:0032993

protein-DNA complex

PMID:21421764[2]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:21421764[2]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_007779.1

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:21421764[2]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001217

DNA-binding transcription repressor activity

PMID:21421764[2]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_007779.1

F

Seeded From UniProt

complete

enables

GO:0001216

DNA-binding transcription activator activity

PMID:21421764[2]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001216

DNA-binding transcription activator activity

PMID:21421764[2]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_007779.1

F

Seeded From UniProt

complete

enables

GO:0001216

DNA-binding transcription activator activity

PMID:21421764[2]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:21421764[2]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:21421764[2]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_007779.1

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:21421764[2]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:2000144

positive regulation of DNA-templated transcription, initiation

PMID:8817489[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900190

regulation of single-species biofilm formation

PMID:14523117[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000986

bacterial-type proximal promoter sequence-specific DNA binding

PMID:14523117[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001217

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016032

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000792
InterPro:IPR016032

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-KW:KW-0997
UniProtKB-SubCell:SL-0037

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Gualdi, L et al. (2007) Biofilm formation-gene expression relay system in Escherichia coli: modulation of sigmaS-dependent gene expression by the CsgD regulatory protein via sigmaS protein stabilization. J. Bacteriol. 189 8034-43 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Ogasawara, H et al. (2011) Role of the biofilm master regulator CsgD in cross-regulation between biofilm formation and flagellar synthesis. J. Bacteriol. 193 2587-97 PubMed GONUTS page
  3. Hammar, M et al. (1995) Expression of two csg operons is required for production of fibronectin- and congo red-binding curli polymers in Escherichia coli K-12. Mol. Microbiol. 18 661-70 PubMed GONUTS page
  4. 4.0 4.1 Brombacher, E et al. (2003) The curli biosynthesis regulator CsgD co-ordinates the expression of both positive and negative determinants for biofilm formation in Escherichia coli. Microbiology (Reading, Engl.) 149 2847-57 PubMed GONUTS page