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ECOLI:CAS3
Contents
| Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
| Gene Name(s) | ygcB (synonyms: cas3) | |
| Protein Name(s) | CRISPR-associated endonuclease/helicase Cas3 | |
| External Links | ||
| UniProt | P38036 | |
| EMBL | U29579 U00096 AP009048 Y07525 | |
| PIR | E65057 | |
| RefSeq | NP_417241.1 YP_490970.1 | |
| ProteinModelPortal | P38036 | |
| SMR | P38036 | |
| IntAct | P38036 | |
| STRING | 511145.b2761 | |
| PRIDE | P38036 | |
| EnsemblBacteria | AAC75803 BAE76838 | |
| GeneID | 12931746 947229 | |
| KEGG | ecj:Y75_p2699 eco:b2761 | |
| PATRIC | 32120934 | |
| EchoBASE | EB2516 | |
| EcoGene | EG12634 | |
| eggNOG | COG1203 | |
| HOGENOM | HOG000224183 | |
| InParanoid | P38036 | |
| KO | K07012 | |
| OMA | CWIRNTV | |
| OrthoDB | EOG6QCD7N | |
| PhylomeDB | P38036 | |
| BioCyc | EcoCyc:EG12634-MONOMER ECOL316407:JW2731-MONOMER | |
| PRO | PR:P38036 | |
| Proteomes | UP000000318 UP000000625 | |
| Genevestigator | P38036 | |
| GO | GO:0005524 GO:0033680 GO:0097098 GO:0003690 GO:0004519 GO:0004527 GO:0000287 GO:0006200 GO:0051607 | |
| Gene3D | 3.40.50.300 | |
| InterPro | IPR006483 IPR011545 IPR014001 IPR001650 IPR006474 IPR027417 | |
| Pfam | PF00270 | |
| SMART | SM00487 SM00490 | |
| SUPFAM | SSF52540 | |
| TIGRFAMs | TIGR01587 TIGR01596 | |
| PROSITE | PS51643 PS51192 PS51194 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0097098 |
DNA/RNA hybrid annealing activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033680 |
ATP-dependent DNA/RNA helicase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008296 |
3'-5'-exodeoxyribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003690 |
double-stranded DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000738 |
DNA catabolic process, exonucleolytic |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000737 |
DNA catabolic process, endonucleolytic |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000014 |
single-stranded DNA endodeoxyribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004536 |
deoxyribonuclease activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033680 |
ATP-dependent DNA/RNA helicase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004518 |
nuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004527 |
exonuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004519 |
endonuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Howard, JA et al. (2011) Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein. Biochem. J. 439 85-95 PubMed GONUTS page
- ↑ Brouns, SJ et al. (2008) Small CRISPR RNAs guide antiviral defense in prokaryotes. Science 321 960-4 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Westra, ER et al. (2012) CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3. Mol. Cell 46 595-605 PubMed GONUTS page
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